十二指肠间质瘤临床、内镜及病理特点分析  

Analysis for clinical, endoscopi and-pathologic characteristics Of duodenal gastrointestinal stromal tumors

作　　者：罗海滨[1] 吕景云[1] 宋玉兰[2] 

机构地区：[1]北京大学医院内科,100871 [2]邯郸市第一医院普外科

出　　处：《中国临床实用医学》2008年第2期47-48,共2页China Clinical Practical Medicine

摘　　要：目的探讨十二指肠间质瘤临床、内镜及病理特点。方法回顾性分析经手术和病理确诊的15例十二指肠间质瘤患者的临床、内镜及病理资料。结果以黑便伴贫血为主要表现12例，间断腹痛1例，腹胀1例，腹部肿物1例。病灶位于降部10例，水平段4例，球部1例。病理学资料肿瘤直径2～15cm，平均6．1cm。组织病理检查，梭形细胞型9例，上皮样细胞型4例，混合型2例。CD117和CD34阳性表达率分别为86．6％和53．3％。病理诊断良性间质瘤5例，恶性8例，潜在恶性2例。结论十二指肠间质瘤临床及内镜下缺乏特异性表现，内镜下活检阳性率低，诊断依赖病理及免疫组化。Objective To investigate the clinical characteristics,the endoscopic features,and pathologic morphology of duodenal gastrointestinal stromal tumors（GISTs）. Methods The clinical data of 15 GIST patients were retrospectively analyzed. Results Common symptoms of GISTs were non-specific, included digestive tract hemorrhage and anemia（12/15） , abdominal pain （1/15） , abdominal masses （1/15） , fullness （1/15）. The lesions of duodenal GISTs mainly located in the descending duodenum（10/15） ,in the horizontal part（4/15 ） , and the bulb（1/15）. The diameters of the masses ranged from 2 cm to 15 cm with an average of 6.1 cm. Histio- pathologicaly, the types of tumors were classified as spindle cells tumors （9/15）and epithelioid cells tumors （4/15） , and mixed cells tumors（2/15）. The immunohistochemical results of GISTs showed that the positive rates of CD117 was 86.6% , CD34 was 53.3%. 5 cases were benign. 2 cases were potentially malignant and 8 cases were malignant. Conclusion GISTs has no specific clinical and endoscopic feature. Final diagnosis should be based on pathology and immunohistochemics.

关 键 词：十二指肠间质瘤 临床表现 内镜 病理 

分 类 号：R735.31[医药卫生—肿瘤] R735.34[医药卫生—临床医学]