苯并吡喃类化合物的合成及生物活性研究  

Synthesis and biological activity of a series of benzopyran derivatives

作　　者：汤磊[1] 杨玉社[1] 嵇汝运[1] 

机构地区：[1]中国科学院上海生命科学研究院上海药物研究所国家新药研究重点实验室,上海201203

出　　处：《药学学报》2008年第2期162-168,共7页Acta Pharmaceutica Sinica

摘　　要：合成了13个苯并吡喃类化合物,用3T3-L1前脂肪细胞对这些化合物进行了促脂肪细胞分化活性筛选,并用db糖尿病小鼠模型对化合物8进行了降糖活性研究。结果表明,化合物3、8和11在3T3-L1脂肪细胞模型上表现出较强的促脂肪细胞分化活性,化合物8能显著降低db糖尿病小鼠的血糖水平。Thirteen benzopyran derivatives were synthesized and their activity stimulating the differentiation of preadipocytes into adipocytes were evaluated with 3T3-L1 cells. Compound 8 was also tested for its hypoglycemic activity on db diabetes mice model. Results indicated that compounds 3, 8 and 11 exhibited strong differentiation-stimulating activity on 3T3-L1 cells model, and compound 8 can reduce the blood-sugar level of db diabetes mice dramatically.

关 键 词：苯并吡喃 合成 3T3-L1细胞 2型糖尿病 

分 类 号：R916.2[医药卫生—药学]