原发性肝癌伴癌综合征的临床分析  

Clinical analysis of paraneoplastic syndrome in 635 primary hepatic carcinoma patients

作　　者：冯晓玲[1] 鲍冰[2] 王志凤[3] 

机构地区：[1]新疆医科大学第五附属医院消化科,830000 [2]武警新疆总队医院感染科 [3]新疆医科大学第一附属医院消化科

出　　处：《肝脏》2008年第1期17-19,共3页Chinese Hepatology

摘　　要：目的分析原发性肝癌伴瘟综合征(PNS)的临床特征,探讨PNS患者生化及病理参数的改变规律。方法对病理或影像学检查确诊的635例原发性肝癌患者资料进行回顾性分析,比较PNS组与非PNS组临床特征、生化及病理参数等指标方面的差异。结果PNS占同期原发性肝癌住院人数的20.0%(127/635),男女之比为8.77:1。PNS主要表现为6种异常:血小板增多症(占同期原发性肝癌住院人数的6.14%,下同).高胆固醇血症(5.83%),白细胞增多症(5.20%),红细胞增多症(1.10%),高钙血症(0.94%),低血糖症(0.79%)。原发性肝癌PNS组与非PNS组相比,在平均AFP水平、肿瘤负荷、肝炎病毒感染率等方面差异有统计学意义(P<0.05)。结论原发性肝癌PNS患者平均AFP水平、肿瘤负荷和肝炎病毒感染率较高,其临床表现无特异性,容易漏诊和误诊。Objective To analyze the clinical features of paraneoplastic syndrome（PNS） in primary hepatic carcinoma （PHC） patients and approach the rule of varying of biochemistry and pathology parameter in PNS patients. Methods The experimental data was reviewed retrospectively from 635 PHC patients identified by pathology or image-analysis, the difference in clinical feature, biochemistry and pathology parameter between PNS group and none-PNS group was compared. Results 20.00% （127/635） of PHC patients complicated with PNS, the ratio of male to female was 8.77 ： 1. PNS was mainly manifested by six clinical abnormal features：thrombocytosis（6. 14% ）, hypercholesteremia （5.83%）, leucocytosis （5.20% ）, erythrocytosis （1.10%）, hypercalcinemia （0.94%） and hypoglycemia （0.79%）. The differences of the level of AFP, tumor size, infection rate of hepatitis virus in two groups were significant（P〈 0.05）. Conclusion The PNS group in the potients of PHC showed higher level of AFP, bigger size of tumor, more infection ratio of hepatitis virus compared with none-PNS group. The Clinical manifestations of paraneoplastic syndromes in primary hepatic carcinoma are nonspecific, it is often missed diagnosed and misdiagnosed.

关 键 词：原发性肝癌 伴癌综合征 临床分析 

分 类 号：R735.7[医药卫生—肿瘤] R512.91[医药卫生—临床医学]