依地酸二钠预防后发性白内障的实验研究  

An experimental investigation of cleanrance of lens epithelial cells by Ethylenediaminetetra-acetic acid (EDTA) to prevent posterior capsular opacification

作　　者：刘建亭[1] 张素华[1] 刘杰为[1] 钱军[1] 

机构地区：[1]山西省眼科医院,太原030002

出　　处：《临床眼科杂志》2008年第1期78-80,共3页Journal of Clinical Ophthalmology

摘　　要：目的探讨应用依地酸二钠(EDTA)清除晶状体上皮细胞,预防后发性白内障的可行性。方法白内障摘除术中连续环形撕囊后取得人晶状体前囊膜30例,随机分为五组,分别用平衡盐溶液(对照组、A组),5 mmol/L、10 mmol/L、15 mmol/L、30 mmol/L的EDTA溶液(B、C、D、E组)进行处理,观察晶状体上皮细胞的清除情况。结果A组未见明显细胞脱落;B组晶状体上皮细胞仅有少部分脱落;C组和D组晶状体上皮细胞大部分脱落;E组晶状体上皮细胞完全脱落。结论合适浓度的EDTA可以作为白内障手术中清除晶状体上皮细胞的有效方法,为防治后发性白内障提供理论依据。Objective To study the prevention of posterior capsular opacification by using EDTA sohtion. Methods The thirty anterior capsules were obtained by CCC in cataract surgery, and The experiment were divided into 5 groups randomly. BSS was used in the control group（ A gruop） and EDTA solutions in the drug group with four different concentrations （5 mmol/L, 10 mmol/L,15 mmol/L ,30 mmol/L, A,B,C,D group ） to clear up LECs. Results No cell was loosened and removed in group A, and a few were cleared in group B, most in group C and D. All the LECs were loosened and removed from anterior capsule in group E. Conclusion EDTA may prevent the posterior capsular opacification by clearing the LECs from anterior capsule.

关 键 词：依地酸二钠 晶状体上皮细胞 后发性白内障 

分 类 号：R776.1[医药卫生—眼科] R691.405[医药卫生—临床医学]