钴(Ⅱ)-氨基葡萄糖-α-氨基酸三元配合物的稳定性研究  

The Stability of Glucosamine-α-aminoacids-cobalt(Ⅱ) Ternary Complexes

作　　者：董丽[1] 耿明江[1] 华远照[1] 李聪辉[1] 孙祥德[1] 

机构地区：[1]河南省新乡医学院,河南新乡453003

出　　处：《时珍国医国药》2008年第2期328-329,共2页Lishizhen Medicine and Materia Medica Research

基　　金：河南省教育厅资助项目(No2000150018)

摘　　要：目的研究钴(Ⅱ)-氨基葡萄糖-α-氨基酸三元配合物的稳定性。方法pH电位滴定法测定(298±0.1)K,I=0.10mol/L KNO3条件下钴(Ⅱ)-氨基葡萄糖-α-氨基酸三元配合物的稳定常数。结果钴(Ⅱ)与氨基葡萄糖和甘氨酸(G ly)、脯氨酸(Pro)、丝氨酸(Ser)、缬氨酸(Val)、异亮氨酸(ILE)、苯丙氨酸(Phe)、蛋氨酸(M et)形成的三元配合物的稳定常数分别为8.64,8.49,7.65,8.61,8.72,8.32,8.45。结论在钴(Ⅱ)-氨基葡萄糖-α-氨基酸三元体系中,生物配体氨基葡萄糖和α-氨基酸具有良好的相容性,三元配合物的稳定性随α-氨基酸的碱性及二元配合物稳定性的增大而增大。Objective To study the stability of glucosamine-α-aminoacids - cobalt（ Ⅱ ） ternary complexes. Methods The forma- tion constant of α - aminoacids - glucosamine - cobalt （ Ⅱ ） ternary complexes were determined at 298 K, I = 0.1 mol/L KNO3 by pH method. Results The formation constant of α - aminoacids - glucosamine - cobalt （ Ⅱ ） ternary complexes were Gly 8. 64, Pro8.49, Ser7. 65, Val8.61, iLe8.72, Phe8.32 and Met8.45. Conclusion The two biologically active ligand, α-aminoacid and glucosamine accommodate each other when coordinated to cobalt（ Ⅱ） ion. The stability of ternary complex is larger than that of the corresponding binary complex. The formation constant of the ternary complexes increases with the increase of protonation constant of aminoacid and the stability of its binary complexes.

关 键 词：钴(Ⅱ) 氨基葡萄糖 Α-氨基酸 三元配合物 稳定性 

分 类 号：R284.1[医药卫生—中药学]