大鼠肠道菌群对芹菜素代谢影响  

Metabolism of apigenin by rat intestinal flora

作　　者：常佩亮[1] 夏薇[1] 张宇[1] 张宇秋[1] 赵秀娟[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院,哈尔滨150081

出　　处：《中国公共卫生》2008年第3期382-383,共2页Chinese Journal of Public Health

基　　金：黑龙江省卫生厅资助项目(2004-225)

摘　　要：目的研究大鼠肠道菌群对芹菜素的代谢影响。方法采用SD大鼠的新鲜粪便,用人工肠液溶解后加入芹菜素标准溶液,37℃厌氧孵化后采用(RP-HPLC)方法对芹菜素的代谢情况进行定量分析。结果孵化后1h芹菜素迅速被肠道菌群代谢,随着孵化时间的延长,芹菜素被大鼠肠道菌群代谢降解的速度放缓。结论在离体条件下,芹菜素容易被大鼠肠道菌群代谢。Objective To study the metabolism of apigenin in vitro intestinal flora from rat.Methods Apigenin was added to the rat fecal flora which was solved in the artificial intestinal juice.The mixture were anaerobically incubated at 37℃,then the metabolism of apigenin was analyzed and quantified by RP-HPLC.Results Apigenin was fast metabolized by rat intestinal flora after incubated 1 h.With the persistence of the incubation time,the speed slowed.Conclusion In vitro,apigenin is easily metabolized by rat intestinal flora.

关 键 词：芹菜素 肠道菌群 降解 高效液相色谱 

分 类 号：R378.2[医药卫生—病原生物学]