食管贲门重复癌及重复高级别上皮内瘤变患病队列分析  

The Esophagus with Cardia Multiplecarcinoma and Multiple High Grade Intraepithelial Neoplasia in Cohort Study

作　　者：陈志峰[1] 靳国良 侯俊[1] 郭翠兰 白文龙 乔翠云 高峰 宋国慧 孟凡书 

机构地区：[1]河北省肿瘤研究所,石家庄050011 [2]河北省磁县肿瘤防治所

出　　处：《肿瘤防治研究》2008年第2期128-129,148,共3页Cancer Research on Prevention and Treatment

基　　金：国家十五科技攻关资助课题(2001BA703B10)

摘　　要：目的从经典的重复癌诊断和WHO肿瘤新分类两个标准，分析食管癌高发区食管贲门重复癌和重复高级别上皮内瘤变患病情况。方法选择河北省磁县2013例40-69岁队列人群为样本。根据WHO新分类标准，将食管鳞状上皮的重度不典型增生、原位癌和贲门腺上皮重度不典型增生、粘膜内癌划为高级别上皮内瘤变（HIN）。对食管和贲门病理同时为HIN的作为重复HIN诊断；食管贲门重复癌仍采用Warren标准。结果以Warren的诊断标准统计，食管贲门重复癌患病率为0．01％（2／2013），占食管贲门原位癌、粘膜内癌和早期浸润癌总检出的2．2％（2／88）；重复HIN患病率0．2％（4／2013），占HIN总检出的3．3％（4／123）。结论磁县40-65岁人群食管贲门重复癌和重复HIN患病率相对较高。Objective According to the diagnosis of classical supercarcinoma and the criterion of the WHO pathology of new classify of tumours in 2000 years,which is high grade intraepithelial neoplasia （HIN）, to investigate prevalence condition for multiplecarcinoma and HIN in the area of high incidence of esophageal carcinoma. Methods Two thousand and thirteen persons with 40- 69 age and through endoscopic examination were enrolled in cohort study, depending on the criterion of the WHO pathology of new classify of tumours, severe dysplasia, carcinoma-in-situ for esophageal sequmous cell and severe dysplasia, intramucosal cancer for cardia adeno-epithelia cell were classiified as high-grade intraepithelia neoplasia （HIN）. For pathology at the same time were HIN in esophagus with cardia as multiple-HIN diagnosis, still Warren standard was adopted for esophagus with cardia multiplecarcinamo（ECM）. Results Prevalence rate was 0. 01% for ECM, it occupied 2. 2 % on total detecting carcinoma-in-situ, intramucosal canc- er and early invasive carcinoma,multiple - HIN was 0. 2 %, that account for 3. 3 % in all HIN. Conclusion Forty-Sixty-five years old crowd in Ci-county, prevalence rate were relatively higher for ECM and multiple-HIN.

关 键 词：重复癌 重复高级别上皮内瘤变 食管 贲门 队列 

分 类 号：R730.2[医药卫生—肿瘤] R735.1[医药卫生—临床医学]