5-HT1B基因A161T多态性与抑郁症的关联研究  

Association analysis between the 5-HT1B receptor gene A161T polymorphism and major depression in Han nationality of China North

作　　者：刘志芬[1] 孙燕[1] 任燕[1] 段慧君[1] 罗锦秀[1] 付文媛[1] 李素萍[1] 张克让[1] 

机构地区：[1]山西医科大学第一医院精神卫生科,030001

出　　处：《上海精神医学》2008年第1期16-19,22,共5页Shanghai Archives of Psychiatry

基　　金：国家自然科学基金面上项目(30770770);山西省科技攻关项目(2007031091-3);山西省青年科技研究基金(2007021050)

摘　　要：目的探讨抑郁症患者与5-HT1B受体基因A161T多态性之间的关系。方法应用聚合酶链式反应(PCR)扩增技术及限制性片段长度多态性(RFLP)分别检测365例抑郁症患者(病例组)、365名健康人(对照组)的5-HT1B受体基因A161T多态性。结果5-HT1B受体基因A161T多态性在病例组和对照组的基因型和等位基因分布频率无显著性差异;按照发病年龄(30岁为界)、有无家族史及有无自杀观念分层后,各亚组与对照组间基因型和等位基因分布也无显著性差异。经多因素分析控制年龄、性别因素后各组基因型分布仍无显著性差异。结论5-HT1B受体基因A161T多态性可能不是抑郁症及其各临床亚型发病的一个危险因素。Objective： To investigate the association between 5-HT1B receptor gene A161T polymorphism and major depression in Han nationality of China North. Methods： The polymorphism of 5 -HT1B A161T of 365 major depression patients （patient group）and 365 controls （control group）had been genotyped using the polymerase chain reaction and restriction fragment length polymorphisms（PCR-RFLP）technique. Results：No significant difference was observed between the patients and control subjects in the genotype distributions and allele frequencies for the investigated A161T polymorphisms. Similarly, no significant differences were found between more homogeneous subgroups of patients and control subjects. Conclusion：This study suggests that the investigated polymorphisms in the 5-HT1B gene are not major risk factors in increasing susceptibility to either major depression or its clinical subtypes in a Han Chinese population.

关 键 词：抑郁症 5-HT1B受体基因 多态性 关联 

分 类 号：R749.4[医药卫生—神经病学与精神病学]