酚妥拉明阻断去甲肾上腺素对吗啡成瘾大鼠束旁核痛反应神经元电活动的影响  

Phentolamine antagonizes the effects of norepinephrine on the activity of pain-related neurons in the parafascicular nucleus of morphine-dependent rats

作　　者：金秀东[1] 关艳中[1] 张书捷[1] 徐满英[2] 岳文杰[1] 

机构地区：[1]牡丹江医学院生理学教研室,黑龙江牡丹江157011 [2]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150086

出　　处：《南方医科大学学报》2008年第2期266-268,共3页Journal of Southern Medical University

摘　　要：目的研究酚妥拉明阻断去甲肾上腺素对吗啡成瘾大鼠束旁核痛反应神经元电活动的影响。方法以串刺激右侧坐骨神经为伤害性刺激,用玻璃微电极细胞外记录大鼠束旁核痛反应神经元电活动。结果脑室去甲肾上腺素抑制束旁核痛兴奋神经元放电,促进痛抑制神经元放电,此作用可被酚妥拉明阻断。结论酚妥拉明阻断去甲肾上腺素对吗啡成瘾大鼠束旁核痛反应神经元电活动的抑制作用,提示去甲肾上腺素的镇痛作用与α肾上腺素能受体关系密切。Objective To examine the antagonization of phentolamine against the effects of norepinephrine （hiE） on the activity of pain-related neurons in the parafascicular nucleus of morphine-dependent rats. Methods Electric impulses were applied as nociceptive stimulus to the right sciatic nerve of morphine-dependent rats, and the discharges of the pain-related neurons in the parafascicular nucleus were recorded by extracellular recording method with glass microelecttodes. Results /ntracerebroventricular injection ofnorepinephrine resulted in the inhibition of evoked response of the pain-excited neurons as well as the excitation of evoked response of the pain-inhibiting neurons. Both the inhibitory effect on the electric discharges of the pain-excited neurons and the excitatory effect on the pain-inhibiting neurons of norepinephrine were almost completely blocked by intracerebroventricular administration of phentolamine. Conclusion Phentolamine antagonizes the inhibitory effect of norepinephrine on the activity of pain-related neurons in the parafascicular nucleus in morphine-dependent rats, and norepinephrine may play an important role in the integration of the pain signal through the or-receptors.

关 键 词：酚妥拉明 去甲肾上腺素 吗啡成瘾 束旁核 痛反应神经元 

分 类 号：R749.64[医药卫生—神经病学与精神病学]