年龄是加重大鼠自发性脑出血后脑损害的重要因素  

Age Is a Significant Factor in Aggravating Brain Injury Following Spontaneous Intracerebral Helnorrhage in Rats

作　　者：宫晔[1] 谢清[1] 陈衔城[1] 赵帆[1] 谢立乾[1] 

机构地区：[1]复旦大学附属华山医院神经外科,复旦大学上海医学院神经外科学系,上海200040

出　　处：《国际脑血管病杂志》2008年第1期13-16,共4页International Journal of Cerebrovascular Diseases

摘　　要：目的：探讨年龄对大鼠自发性脑出血后神经功能缺损、脑水肿、热休克蛋白-32（HSP32）水平变化的影响。方法：3月、10月和18月龄组（每组34只）SD大鼠制作脑出血模型，分别检测脑水含量、HSP32表达及行为学评价。结果：18月龄组脑水肿和神经功能缺损较3月和10月龄组大鼠更加严重（P均〈0.05），HSP32水平也显著上调。结论：年龄是影响大鼠脑出血后早期脑损害的重要因素，同时也关系到神经功能恢复。Objective： To investigate the effects of age on neurological deficit, cerebral edema, changes of heat shock protein 32 （HSP32） levels following spontaneous intracerebral hemorrhage （ICH） in rats. Methods： A total of 102 Sprague-Dawley rats, 3-, 10- and 18-month-old groups （n = 34 in each group） were induced intracerebral hemorrhage. Brain water content, HSP32 expression and behavior assessment were detected, respectively. Results： As compared with the 3- and 10-month-old groups, cerebral edema and neurological deficit were more severe in the 18-month-old group （P all 〈0.05）. Jhe levels of HSP32 were also up-regulated significantly. Conclusions： Age is a significant factor in the early brain injury following ICH in rats. At the same time, it is also in relation to neurological functional recovery.

关 键 词：脑出血 年龄 脑水肿 热休克蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]