新型1,5-二苯基-1,4-戊二烯-3-酮肟酯类化合物的合成及其抑菌活性研究  

Synthesis and Antifungal Activity of Novel 1,5-Diphenyl-1,4-pentadien-3-one Oxime Esters

作　　者：李少博[1] 胡德禹[1] 宋宝安[1] 杨松[1] 金林红[1] 薛伟[1] 曾松[1] 王俊[1] 陈卓[1] 卢平[1] 周霞[1] 樊玲娥[1] 

机构地区：[1]贵州大学精细化工研究开发中心教育部绿色农药与农业生物工程重点实验室,贵阳550025

出　　处：《有机化学》2008年第2期311-316,共6页Chinese Journal of Organic Chemistry

基　　金：国家科技部国际合作重大项目(No.2005DFA30650);国家自然科学基金(No.20662004));贵州省省长基金(No.200624)资助项目

摘　　要：以1,5-二苯基-1,4-戊二烯-3-酮肟和酰氯为原料,合成了15个新型的1,5-二苯基-1,4-戊二烯-3-酮肟酯类化合物,通过元素分析,IR,1HNMR,13CNMR等对其结构进行了表征.初步生物活性试验结果表明,在50mg?L-1浓度下,化合物3i和3o对小麦赤霉病菌抑制率分别为51.1%和53.4%,与对照药剂恶霉灵抑制活性相当.Fifteen 1,5-diphenyl-l,4-pentadien-3-one oxime esters were synthesized by the reaction of 1,5-diphenyl-l,4-pentadien-3-one oxmie with acyl chloride. Their structures were identified by elemental analysis, IR, 1H NMR and 13C NMR spectra. The preliminary bioassay showed that compounds 3i and 30 had certain antifungal activities against Fusarium graminearum with rate of 51.1% and 53.45% at a concentration of 50 mg·L^-1 respectively, similarly to the control （hymexozole）.

关 键 词：戊二烯酮 肟酯 合成 抑菌活性 

分 类 号：TQ450.1[化学工程—农药化工]