GP方案与TP方案一线治疗晚期非小细胞肺癌的临床观察  

Clinical observation of original chemotherapy for advanced non-small cell lung cancer between GP regimen and TP regimen

作　　者：杭达明[1] 谢国栋[1] 张葆春[2] 

机构地区：[1]南通市肿瘤医院放疗科,江苏南通226361 [2]南通市肿瘤医院内科,226361

出　　处：《临床肿瘤学杂志》2008年第2期133-136,共4页Chinese Clinical Oncology

摘　　要：目的:探讨GP方案和TP方案对初治的晚期非小细胞肺癌(NSCLC)的疗效和毒性。方法:72例晚期NSCLC(ⅢB期50例,Ⅳ期22例)随机分成GP组和TP组,入组的每例患者接受至少2个周期以上的GP或TP同样方案的化疗,比较两组不同化疗方案的近期疗效和毒副反应,以及1、2年的生存率。结果:GP和TP两组近期疗效的有效率分别为44.4%和47.2%,两组中位生存期分别为8.7月和8.5月,1年生存率分别为16.6%和19.4%,2年生存率分别为8.3%和11.1%。两组资料统计学处理均无显著性差异。毒副反应方面,GP组以血小板降低为主,TP组以白细胞降低为主,均在可耐受的范围内。结论:GP和TP两种化疗方案对晚期NSCLC均有较好的临床疗效,化疗毒副反应虽有所不同,但均可耐受。因此GP和TP两种化疗方案均可作为晚期NSCLC的一线治疗方案。Objective：TO investigate the efficacy and toxicity of the GP regimen and TP regimen on advanced non-small cell lung cancer. Methods：Seventy-two patients with advanced non-small cell lung cancer were divided into the GP and the TP group randomly. In all case ,50 patients were in stage Ⅲ B, 22 patients in stage Ⅳ ,all the patients had accepted intravenous chemotherapy and preponderated over 2cycles. A clinical observation on short term effectiveness adverse effects and the 1-,2-year survival rate were cartied out in two groups. Resets：The short term effective rate for advanced non-small cell lung cancer in GP group and TP group was 44.4% and 47.2%, respectively. The median survival time was 8.7 months and 8. 5 months, respectively. 1-year survival rate was 16. 6% and 19.4% ,respectively. 2-year survival rate was 8. 3% and 11.1%. The short term effectiveness and the 1,2-year-survival state in two groups had no statistically significant difference （ P 〉 0. 05 ）. In the adverse effects of treatment, the major cytotoxicity was thrombocytopenia in GP group and leukopenia in TP group but they were tolerable. Conclusion： Both GP regimen and TP regimen on advanced non-small cell lung cancer show more effectiveness. The side effects of the two regimens are different but all adverse reactions are tolerable, they could become the original chemotherapy in advanced non-small cell lung cancer.

关 键 词：非小细胞肺癌 化学治疗 吉西他滨 紫杉醇 顺铂 

分 类 号：R730.53[医药卫生—肿瘤]