42例胃肠道间质肿瘤的临床病理形态观察  

Clinicopathologic study of 42 cases gastrointestinal stromal tumor

作　　者：李桂梅[1] 张佃乾[1] 乐美兆[1] 殷正进[1] 潘素梅[1] 

机构地区：[1]解放军八一医院病理科,南京210002

出　　处：《临床肿瘤学杂志》2008年第2期153-155,共3页Chinese Clinical Oncology

摘　　要：目的:研究国人胃肠道间质肿瘤(gastrointestinal stromal tumor,GIST)的临床病理形态特点。方法:应用光镜观察42例GIST的形态特征,用免疫组化S-P法检测CD117、CD34、SMA及S-100蛋白在GIST中的表达情况。结果:GIST的瘤细胞排列成交织束状、弥散片状、栅栏状或轮辐状,较为特征的是细胞团巢形成;胞质嗜酸性较经典的平滑肌瘤者为弱。瘤细胞为梭形或上皮样,或梭形与上皮样细胞混合存在。CD117和CD34的阳性率为92.9%(39/42)和76.2%(32/42)。结论:GIST是胃肠道最常见的间叶性肿瘤,有较为独特的组织学形态,CD117和CD34标记阳性是确诊GIST最有价值的诊断依据。Objective： To investigate the pathological features of gastrointestinal stromal tumor （GIST）. Methods ： Light microscopy was used to study the morphologic characteristics of 42 cases of GIST. The expression of CD117, CD34 ,SMA,S-100 protein were detected in all cases with S-P immunohistoehemical method. Results：The histological spectrum included interlacing fascicles, dif- fuse sheets, storiform and palisading pattern, especially the special formation cell duster was observed. The tumor ceils of GIST had degree of cytoplasmic eosinophilia than classic leiomyomas. The tumor cells of GIST were spindle, epithelioid or both in different proportion. The positivity of CD117 and CD34 were 92.9% and 76. 2%. Conclusion： GISTs are the most common mesenchymal tumors in gastrointestinal tract and have specific pathological characteristics. The expressions of CD117 and CD34 are the most useful for the diagnosis of GIST.

关 键 词：胃肠道间质肿瘤 病理 免疫组织化学 诊断 

分 类 号：R735.2[医药卫生—肿瘤]