结直肠癌伴肝转移91例患者的多因素预后分析  

Prognostic factors of 91 patients with simultaneous liver metastases from colorectal cancer

作　　者：陈颢[1] 张剑军[1] 孟志强[1] 陈震[1] 林钧华[1] 周振华[1] 王琨[1] 马鑫[1] 刘鲁明[1] 

机构地区：[1]复旦大学附属肿瘤医院中西医结合科,上海200032

出　　处：《肿瘤》2008年第2期153-155,166,共4页Tumor

摘　　要：目的:探讨结直肠癌同时性肝转移患者的预后相关因素。方法:采用多因素回归分析方法回顾性分析了91例结直肠癌同时性肝转移患者的生存因素。结果:91例结直肠癌同时性肝转移的患者中位生存期为16.8个月,1年生存率为61.54%,3年生存率为14.79%,5年生存率为8.87%。单因素分析显示原发灶手术、肝转移分期、介入治疗、放射治疗、物理治疗、化疗和新药使用与患者的生存期显著相关;多因素分析显示,肝转移分期、原发病灶手术切除、介入治疗、物理治疗对患者的预后有显著影响,是结直肠癌同时性肝转移影响预后的主要因素。结论:对于结直肠癌同时性肝转移的患者应积极切除原发病灶,进行介入、物理等综合治疗可以提高患者的生存期。Objective：To analyze the risk factors related to prognosis of 91 patients with simultaneous liver metastases from colo-rectal cancer. Methods：We retrospectively analyzed the survival-related factors of 91 patients with simultaneous liver metastases from colorectal cancer using the multivariate COX analysis. Results：The median survival time of 91 patients with simultaneous liver metastases from colorectal cancer was 16.8 months. The survival rates at 1, 3 and 5 years were 61.54%, 14.79%, and 8.87%, respectively. Univariate analysis showed that resection of primary tumor, the staging of liver metastasis, transcatheter arterial chemoembilization （TACE）, radiotherapy, physical therapy, chemotherapy, use of new anti-tumor agents were all independently related with the prognosis of colorectal cancer patients. COX regression analysis demonstrated that staging of liver metastasis, resection of primary tumor, TACE and physical therapy were the key factors affecting the prognosis of the colorectal cancer patients with simultaneous liver metastases. Conclusion：The survial time of colorectal cancer patients with simultaneous liver metastases could be elongated by resecting primary tumors and performing integrated anti-tumor therapy such as TACE and physical therapy.

关 键 词：结直肠肿瘤 肿瘤转移 预后 

分 类 号：R730.7[医药卫生—肿瘤]