Clinic Pathological Features of Angiomyofibroblastoma in Vulva  

作　　者：陈维香 童淑兰 费绍华 曹志星 曹晓哲 

机构地区：[1]Department of Pathology,Gongli Hospital of Pudong New Area [2]Department of Pathology,The 2nd People's Hospital of Zhuhai

出　　处：《Chinese Journal of Cancer Research》2008年第1期21-25,共5页中国癌症研究（英文版）

基　　金：a grant from 11th five-year plan medical science project of PLA(No.06MA084)

摘　　要：Objective： To analyze the clinicopathological features and differential diagnosis of angiomyofibroblastoma （AMFB） of the vulva. Methods： Two cases of AMFB were examined by light microscopy and immunohistochemical study and to discuss the clinicopathological features and differential diagnosis of AMFB with the reference to the literature. Results： Tumors were all circumscribed, and 〈5 cm in diameter. Microscopically, the tumors were composed of spindle or polygonal cells that were cellularly or hypocellularly arranged with perivascular accentuation in a mucoid or fibrocollagenous background. The tumors contained numerous small- to medium-sized blood vessels, which were characteristically thin walled. Immunohistochemically, two cases of tumor cells were positive for vimentin, SMA, CD34（＋） and FⅧ（＋）. Desmin and MSA were positive in one case; Cytokeratin, S-100, CD31 were negative in both. Conclusion： AMFB is a rare, benign soft tissue tumor that occurs in the genital tract of adult women. The origin remains unclear, but it is suggested that an origin from a perivascular pluripotent stem cell that is capable of myofibroblastoma differentiation. Angiomyofibroblastoma should be differentiated from other neoplasms of the vulva such as aggressive angiomyxoma, superficial angiomyxoma and cellular angiofibroma.Objective： To analyze the clinicopathological features and differential diagnosis of angiomyofibroblastoma （AMFB） of the vulva. Methods： Two cases of AMFB were examined by light microscopy and immunohistochemical study and to discuss the clinicopathological features and differential diagnosis of AMFB with the reference to the literature. Results： Tumors were all circumscribed, and 〈5 cm in diameter. Microscopically, the tumors were composed of spindle or polygonal cells that were cellularly or hypocellularly arranged with perivascular accentuation in a mucoid or fibrocollagenous background. The tumors contained numerous small- to medium-sized blood vessels, which were characteristically thin walled. Immunohistochemically, two cases of tumor cells were positive for vimentin, SMA, CD34（＋） and FⅧ（＋）. Desmin and MSA were positive in one case; Cytokeratin, S-100, CD31 were negative in both. Conclusion： AMFB is a rare, benign soft tissue tumor that occurs in the genital tract of adult women. The origin remains unclear, but it is suggested that an origin from a perivascular pluripotent stem cell that is capable of myofibroblastoma differentiation. Angiomyofibroblastoma should be differentiated from other neoplasms of the vulva such as aggressive angiomyxoma, superficial angiomyxoma and cellular angiofibroma.

关 键 词：Vulva neoplasm ANGIOMYOFIBROBLASTOMA Differential diagnosis 

分 类 号：R737.35[医药卫生—肿瘤]