p57^(KIP2)和Ki-67在人脑胶质瘤中的表达及其意义  

Expression of p57^(KIP2) and Ki-67 in Human Glioma and Its Significance

作　　者：吴斌[1] 俞洋[1] 袁先厚[2] 

机构地区：[1]浙江省肿瘤医院,浙江杭州310022 [2]武汉大学中南医院,湖北武汉430071

出　　处：《肿瘤学杂志》2008年第2期126-128,共3页Journal of Chinese Oncology

摘　　要：[目的]研究p57KIP2、Ki-67在人脑胶质瘤中的表达及其意义。[方法]免疫组化S-P法检测50例脑胶质瘤中p57KIP2与Ki-67的表达情况。[结果]p57KIP2蛋白在脑胶质瘤中的表达阳性率为34%,显著低于其在正常脑组织中的阳性率80%(P<0.01)。Ki-67在脑胶质瘤中的表达阳性率为66%,显著高于其在正常脑组织中的阳性率15%(P<0.01)。两者的表达率均与肿瘤的恶性程度及2年生存率有关。p57KIP2与Ki-67的表达密切相关(P<0.05,rs=-0.292)。[结论]p57KIP2的表达水平与肿瘤细胞增殖活性有密切的关系,其表达水平的改变在肿瘤的生长中起关键作用。p57KIP2和Ki-67的联合检测有利于更准确地判断细胞的增殖活性和预后。[Purpose] To study the expression of p57^KIP2, Ki-67 in human glioma and its significance. [Methods] The expression of p57^KIP2 and Ki-67 proteins in 50 cases with glioma was detected by SP immunohistochemical technique. [Results] The p57^KIP2 protein positive rate in human glioma was 34%, which was lower than that in normal brain tissue （80%,P〈0.01）. The Ki-67 positive rate in human glioma was 66%, which was higher than that in normal brain tissue （15%, P〈0.01）. The positive expression of p57^KIP2 and Ki-67 both correlated significantly with grade of differentiation and the 2-year survival. There were significant correlation between the expression of p57^KIP2 protein and Ki-67 protein （P〈0.05,rs=-0.292）. [Conclusion] The expression level of p57^KIP2 protein correlates significantly with proliferating activity of tumor ceils, and plays an important role in oncogenesis of human glioma. Combined detection of p57^KIP2 and Ki-67 is helpful for evaluating cell proliferating activity of tumor cells and the prognosis.

关 键 词：神经胶质瘤 P57^KIP2蛋白 KI-67 免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]