皮肤恶性黑素瘤预后因素的多元回归分析  

COX multivariate regression analysis of prognostic factors for cutaneous malignant melanoma

作　　者：陈宏翔[1] 李碧芳[1] 吴艳[1] 刘厚君[1] 李家文[1] 涂亚庭[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤科,武汉430022

出　　处：《华中医学杂志》2008年第1期41-43,共3页Central China Medical Journal

摘　　要：目的探讨影响皮肤恶性黑素瘤(CMM)患者长期生存的独立预后因素。方法采用COX比例风险模型对可能影响CMM患者预后的指标进行多因素回归分析。结果单因素COX模型分析结果表明性别为女性、年龄<60岁者生存率较高;组织学类型中浅表扩散性黑素瘤比结节性黑素瘤生存率高;发病部位中四肢比躯干生存率高;病理组织学分级中Clark分级低者比分级高者生存率高;Breslow厚度小者比大者生存率高。多因素COX回归分析显示性别、年龄、Clark分级、Breslow厚度为影响CMM患者预后的独立预后因素。结论性别、年龄、Clark分级、Breslow厚度为CMM的独立预后因素,对CMM早期诊断和多学科综合治疗有着重要意义。Objective To determine the independent prognostic factors influencing long-term survival rate of the patients with cutaneous malignant melanoma （CMM）. Methods Univariate and COX multivariate regression analysis was performed on patients with CMM. Results Gender, age, anatomical site, histological type, Clark level and Breslow thickness were significantly correlated with prognosis by univariate analysis. Multivariate analysis revealed that gender, age, Clark level and Breslow thickness retained independent predictive value for CMM. Conclusion Gender, age, Clark level and Breslow thickness are independent prognostic factors for CMM.

关 键 词：皮肤恶性黑素瘤 预后 COX回归分析 

分 类 号：R739.5[医药卫生—肿瘤] R734.2[医药卫生—临床医学]