HIF-1α、PTEN在膀胱移行细胞癌组织中的表达及其临床意义  

Expression and Potential Clinical Implications of HIF-1α and PTEN in Human Bladder Transitional Cell Carcinoma

作　　者：黄江波[1] 黄军科 申鹏飞[3] 齐琳[3] 张向阳[3] 

机构地区：[1]中山大学博士后流动站梅州市人民医院科研基地,514013 [2]长沙市第八医院泌尿外科,410002 [3]中南大学湘雅医院泌尿外科,410008

出　　处：《实用癌症杂志》2008年第2期111-113,共3页The Practical Journal of Cancer

基　　金：湖南省卫生厅科研基金(编号B2004-088)

摘　　要：目的检测膀胱移行细胞癌(BTCC)组织中缺氧诱导因子1α(HIF-1α)和第10号染色体丢失的张力蛋白同源的磷酸酶基因(PTEN)的表达情况,探讨两者在BTCC中表达的可能临床意义。方法应用免疫组织化学检测BTCC组织中HIF-1α和PTEN的蛋白表达,分析其表达与肿瘤部分临床病理特点的关系,并分析两者表达的相关性。结果BTCC组织中HIF-1α阳性表达率为52.63%(30/57),其表达与肿瘤的临床分期及复发明显相关;BTCC组织中PTEN阳性表达率63.16%,随着肿瘤分级、分期的增加PTEN表达显著降低(P<0.05)。而且,HIF-1α与PTEN的表达具有明显负相关性(γ=-0.360,P=0.006)。结论HIF-1α及PTEN在BTCC的侵袭等生物学过程中具有重要的作用,HIF-1α和PTEN可能可以用于临床监控BTCC的进展。Objective To investigate the clinicopathological significance of HIF-1α and PTEN expression in bladder transitional cell carcinoma（BTCC）. Methods Hypoxia inducible factor 1 α （HIF-1α） and phosphatase and tensin homology deleted on chromosome ten （PTEN）protein expression were determined using immunohistochemistry. The relationship between HIF-1α,PTEN expression and various clinicopathological parameters including pathological grade and clinical stage was analyzed and the correlation between HIF-1 α expression and PTEN expression was also analyzed. Results Over-expression of HIF-1 α was frequently （30 of 57 cases,52.63% ） detected in BTCC tissues. HIF-1α expression was significantly associated with invasive bladder cancer. The positive expression rate of PTEN in BTCC was 63.16%. Significant differences existed in the expression of PTEN in carcinomas form different pothological grades and clinical stages （ P 〈 0.05 ）. There was significant negative correlation between the expression of HIF-1 α protein and the PTEN protein expression （ γ= - 0. 360, P = 0.006）. Conclusion HIF-1α and PTEN may play a critical role in the invasion of bladder carcinoma and may be used to estimate the progression of bladder carcinoma.

关 键 词：膀胱移行上皮细胞癌 缺氧诱导因子-1Α PTEN 

分 类 号：R737.14[医药卫生—肿瘤]