乳腺癌组织中WWOX蛋白表达及其临床意义  

The Clinical Significance of the Expression of WWOX Protein in Breast Cancer

作　　者：秦晓冰[1] 张敬川[1] 

机构地区：[1]徐州医学院附属医院肿瘤科,221002

出　　处：《实用癌症杂志》2008年第2期144-146,共3页The Practical Journal of Cancer

摘　　要：目的探讨包含氧化还原酶的WW域(WWOX)蛋白的表达在乳腺癌发生发展中的作用及其临床意义。方法应用免疫组织化学S-P法,检测31例乳腺癌组织及癌旁组织中WWOX蛋白的表达情况,并分析其与乳腺癌各临床病理指标的关系。结果对比癌旁组织,在31例乳腺癌中有16例发生WWOX蛋白表达下降或缺失(51.6%),WWOX蛋白表达与淋巴结转移和ER状态相关(P<0.05),而与年龄、肿块大小及PR、CerbB-2状态无关(P>0.05)。结论在乳腺癌中存在WWOX蛋白的表达减弱或缺失,这可能对乳腺癌的发生发展起到一定的作用。Objective To investigate the significance of the expression of WWOX protein in the tumorigenesis and development of the breast cancer. Methods S-P hnmunohistochemical method was used to detect the expression of WWOX protein in the breast cancer and adjacent tissues in 31 patients. The expression of WWOX was then correlated to the clinicopathological parameters. Results Compared to the adjacent tissues ,the expression of WWOX protein was significantly decreased or negative in 51.6% of the breast cancer tissues. WWOX protein expression was significantly correlated to the lymph node metastasis and ER status（P 〈 0.05）. WWOX expression was not correlated to the age, size of the tumors, PR and CerbB-2 status （P 〉 0.05 ）. Conclusion Expression of WWOX protein is down regulated in breast cancer. WWOX protein may play a role in the tumorigenesis and development of the breast cancer.

关 键 词：包含氧化还原酶的WW域 乳腺癌 抑癌基因 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]