术前一次给予地塞米松对结肠癌患者免疫功能的影响  

Influence on immunological function in patients with colon cancer through preoperative once intravenous injecting dexamethasone

作　　者：黄勇[1] 刘建伟[1] 

机构地区：[1]暨南大学附属第四医院(广州市红十字会医院)普外科,510220

出　　处：《岭南现代临床外科》2008年第1期26-27,34,共3页Lingnan Modern Clinics in Surgery

摘　　要：目的探讨地塞米松对结肠癌术后免疫抑制的影响。方法我科在2004年1月至2007年6月收治结肠癌90例,随机分为实验组和对照组,每组各45例。实验组于前1.5h一次静脉推注地塞米松1.5mg/kg-1,对照组不使用地塞米松。对两组术前,术后的T淋巴细胞亚群、NK细胞、IgA、IgM、IgG进行分析。结果术后3d,7d,实验组T淋巴细胞亚群、NK细胞、lgM、lgG较术后1d升高(P<0.05);对照组T淋巴细胞亚群、NK细胞、lgM、lgG较术后1d无明显差别(P>0.05);对照组,实验组lgA较术后1d无明显差别(P>0.05)。结论说明对结肠癌患者术前一次剂量使用地塞米松能降低术后机体免疫抑制,促进患者的免疫功能。Objective To explore the effects of dexamethasone on postoperative immunosuppression. Methods From January 2004 to January 2007, 90 cases with colon cancer were divided into experimental group and control group. Eech group was 45 cases. Once intravenous injection of dexamethoasome 1.5 mg/kg^-1 was used 1.5 h before operation in experimental group. Dexamethasone was not used in control group. Postoperative T lymphocyte subgroup, NK cell, IgA, IgM, and IgG were analyzed statistically in two groups. Results T lymphocyte subpopulation,NK cell,IgM and IgG of experiment group at 3days and 7 days after operation were higher then at 1 day （P〈0.05）; there was no evident difference between the results of control group（P〉0.05）; IgA of both experiment group and control group at 3 days and 7 days after operation were not different with at 1 day （P 〉 0.05）. Conclusion Single dose dexamethasone to colon cancer patients before operation could degrade the patients＇ immunosuppression and promote the immune function after operation.

关 键 词：地塞米松 结肠癌 免疫功能 

分 类 号：R735.3[医药卫生—肿瘤]