Id-1和P53在乳腺浸润性导管癌中的表达及其意义  

Expressions of Id-1and P53 in invasive ductal carcinoma and their significance

作　　者：冯颖[1] 王刚[1] 史建平 王红磊[1] 

机构地区：[1]兰州大学第一医院,730000 [2]甘肃省血液中心,兰州市730000

出　　处：《实用医学杂志》2008年第4期567-569,共3页The Journal of Practical Medicine

摘　　要：目的:探讨Id-1和P53在乳腺浸润性导管癌中的表达及其意义。方法:采用免疫组织化学Envision二步法检测80例浸润性导管癌中Id-1和P53蛋白的表达情况,并分析其临床病理意义。结果:80例浸润性导管癌组织中Id-1和P53蛋白表达与TNM分期及淋巴结转移呈正相关,P<0.05。Id-1与P53表达正相关,P<0.05。80例浸润性导管癌患者经Cox回归分析,Id-1和P53同时阳性表达是高危险因素,P<0.05。结论:Id-1和P53蛋白的表达在乳腺癌的复发、转移过程中起重要作用。Id-1和P53蛋白同时表达可作为预测乳腺癌预后不良的参考指标。Objectives To explore the expressions of Id-land P53 in invasive ductal carcinoma and their significance. Methods The expressions of Id-land P53 were detected by immunohistochemical method with the Envision system in 80 cases of invasive ductal carcinoma and their clinicopathological significance was evaluated. Results The expressions of Id-1 and p53 in invasive ductal carcinoma were significantly correlated with the TNM classification and lymph node metastasis （P 〈 0.05）. Id-1 expression correlated markedly with P53 expression （P 〈 0.05）. Cox regression showed that co-expressions of Id-land P53 proteins was a high risk factor for invasive ductal carcinoma （P 〈 0.05）. Conclusion The expressions of Id- land P53 proteins play an important role in the genesis and metastasis of invasive breast carcinoma. Co-expressions of Id- land P53 may be used as an indicator for poor prognosis of invasive ductal carcinoma.

关 键 词：乳腺肿瘤 免疫组织化学 蛋白质P53 Id-1蛋白 预后 

分 类 号：R737.9[医药卫生—肿瘤] R735.34[医药卫生—临床医学]