乳腺癌细胞迁移的调节与转移  

Regulation of Cell Migration in Metastasis of Breast Cancer

作　　者：陈晓慧[1] 冯玉梅[1] 

机构地区：[1]天津医科大学附属肿瘤医院/肿瘤研究所生物化学与分子生物学室,乳腺癌防治研究教育部重点实验室,天津300060

出　　处：《细胞生物学杂志》2008年第1期11-14,共4页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.30471671);天津市应用基础研究计划(No.06YFJMJC12900)资助项目~~

摘　　要：细胞迁移是乳腺癌侵袭和转移中的关键步骤之一。癌细胞在迁移过程中主要受到Rho GTPases的调节,发生肌动蛋白骨架重组,获得定向迁移的能力;高迁移能力的癌细胞通过与胞外基质成分相互作用,为迁移创造合适的微环境;最后迁移的癌细胞在靶器官的趋化作用下在特定部位驻足生长,这些环节共同作用导致乳腺癌转移。研究细胞迁移复杂的分子机制将为控制乳腺癌转移提供新的策略。Cell migration is one of the crucial steps in breast cancer invasion and metastasis. In the process of cell migration, acquisition of the capability of directed migration forced by the reorganization of actin cytoskeleton in regulation of Rho family small GTPases is the primary mechanism. In addition, pleasant local microenvironment provided by the interaction of breast cancer cells and extracellular matrix makes cell migration convenient. Finally, cancer cells are attracted and arrested at the target organs, and proliferate into metastases. Thus, researches of the molecular mechanisms in cell migration may provide novel strategy for anti-metastasis therapy of breast cancer.

关 键 词：细胞迁移 转移 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]