各类型脑卒中患者的踝肱指数研究  

Study on ankle-brachial index in patients with various types of stroke

作　　者：周国强[1,2] 曾进胜[3] 

机构地区：[1]中山大学附属第一医院神经科 [2]深圳市福田人民医院神经内科,深圳518033 [3]中山大学附属第一医院神经科

出　　处：《中国神经精神疾病杂志》2008年第2期79-82,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金资助项目(编号:39940012,30271485,30770764,);教育部高校青年教师奖励计划(2002年);美国CMB基金资助项目(编号:00-730);卫生部临床学科重点基金资助项目(2004年);广东省自然科学基金(编号:990065,21906,2003C30610)资助项目;广东省自然科学基金攻关项目(编号:B30303,2003D30301)

摘　　要：目的通过测量各种类型脑卒中患者的踝肱指数(ankle-brachial index ABI),定量评估各类型脑卒中与颅内动脉粥样硬化程度的相关性,探讨ABI是否可作为评估颅内动脉硬化狭窄的指标之一。方法选取各类型脑卒中住院患者共227例,正常对照组88例。使用博士血管多谱勒超声测量仪,测量所有病例组与对照组的ABI,比较两组受试者的ABI。并分析ABI与脑卒中的相关性。结果227例脑卒中患者中,动脉血栓形成性脑梗死119例,其ABI为(0·905±0·133);腔隙性梗死42例,其ABI为(0·908±0·160);分别与对照组ABI(0·980±0·108)比较,有统计学差异(P<0·05)。心源性脑栓塞组、蛛网膜下腔出血组、脑出血组的ABI值分别与对照组比较,无统计学差异(P>0·05)。相关分析显示高血压(OR=3·963)和ABI(OR=2·225)与脑卒中明显相关(P<0·05)。结论ABI可反映动脉血栓形成性脑梗死和腔隙性梗死均与脑动脉硬化明显相关,可作为颅内动脉粥样硬化狭窄的初步筛查手段。Objective We investigated whether ankle-brachial index （ABI） of stroke patients can be used as a screening method for arterial stenosis in stroke patients. Methods ABI was measured in 227 stroke patients, and 88 normal controls using a Doppler device. After adjusting other risk factors, the influence of ABI in stroke was evaluated. Resuits There were statistical differences in ABI between arterial thrombosis cerebral infarction （n = 119, ABI = 0.905±0. 133）, lacunar infarction （n=42, ABI =0.908±0. 160） and normal control （n =88, 0.980±0.108）, （P =0.002、0.015 respectively）. There were no statistical differences in ABI between cardiogenic cerebral embolism, subarachnoid hemorrhage, cerebral hemorrhage and normal control. After adjusting other risk factors including sex, age, diabetes, hyperlipemia, coronary artery disease and smoking, hypertension （odd ratio = 3.963 ）, and ABI（ odd ratio = 2.225 ） were significantly associated with the presence of stroke. Conclusions ABI can reflect the strong relationships between arterial thrombosis cerebral infarction, lacunar infarction and cerebral atherosclerosis, and it can be taken as preliminary screening means of cerebral atherosclerosis.

关 键 词：踝肱指数 脑卒中 动脉粥样硬化 

分 类 号：R743[医药卫生—神经病学与精神病学]