无抽搐电痉挛治疗难治性抑郁症的对照研究  

A comparative study of modified electroconvulsive therapy for refractory depression

作　　者：刘同洲[1] 王斌[1] 王善信[1] 王丽萍[1] 张瑞珍[1] 王旸[2] 

机构地区：[1]山东省精神卫生中心精神科,250014 [2]山东大学医学院精神卫生研究所

出　　处：《神经疾病与精神卫生》2008年第1期42-44,共3页Journal of Neuroscience and Mental Health

摘　　要：目的探讨无抽搐电痉挛治疗难治性抑郁症的疗效及安全性。方法采用入院顺序分层随机法,将65例难治性抑郁症患者随机分为研究组(无抽搐电痉挛治疗)和对照组(抗抑郁剂治疗),共观察4周,在治疗前及治疗第1周末、第2周末、第4周末采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、副反应量表(TESS)评定疗效及不良反应。结果治疗第1周末,研究组HAMD及HAMA评分较治疗前均有显著性降低(P<0.05),而对照组均无显著性改善。治疗第1周末、第2周末及第4周末,研究组的HAMD及HAMA评分均显著低于对照组,差异均有显著性(P<0.05)。研究组未出现严重不良反应。结论无抽搐电痉挛治疗是治疗难治性抑郁症快速、有效、安全的首选方法之一。Objective To explore the efficacy and side effects of modified electroconvulsive therapy （MECT） in treatment of refractory depression. Methods 65 patients with refractory depression were randomly divided into study group with MECT and control group with antidepressants for treatment of 4 weeks. They were assessed and analyzed contrastively using Hamilton depression scale （HAMD）, Ham- ilton anxiety scale （HAMA） and Treatment Emergent Side Effect Scale （TESS）. Results In the 1~t weekend, the total scores of HAMD and HAMA in study group were significantly decreased than that before treatment （P ~ 0.05） and there was no difference in control group （P ~ 0.05）. In the 1st, 2nd and 4th weekend, the total scores of HAMD and HAMA in study group were significantly lower than that in control group（P^0.05. No severe side effects were found in study groups. Conclusions MECT is effec- tive in treating refractory depression without severe side effects.

关 键 词：无抽搐电痉挛治疗 难治性抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]