β-环糊精及其衍生物对姜黄素的增溶和荧光增强作用  

Influence of β-CD and Its Derivatives on Solubilization and Fluoresence Enhancement of Curcumin

作　　者：李香[1] 林秀丽[1] 

机构地区：[1]山东大学药学院,山东济南250012

出　　处：《中国医药工业杂志》2008年第3期194-198,共5页Chinese Journal of Pharmaceuticals

摘　　要：研究了β-CD、HP-β-CD及取代位置不同的环糊精硫酸酯(2-β-CDS、6-β-CDS和随机取代的β-CDS)对姜黄素的增溶和荧光增强作用。采用荧光光谱滴定法测定了姜黄素在pH2缓冲液中与上述5种环糊精主体分子形成超分子包合物的稳定常数(K)。结果表明,HP-β-CD对姜黄素的增溶作用最显著。β-CD与姜黄素形成1∶1包合物,而HP-β-CD及2-β-CDS、6-β-CDS和β-CDS与姜黄素能形成1∶1和2∶1包合物,且包合常数远大于β-CD。其中HP-β-CD与β-CDS的包合作用最强,当两者的浓度为0.03mol/L时,荧光分别增强17和19倍。The influence of β-CD, HP-β-CD and different displaced cyclodextrin sulfates （2-β-CDS, 6-β-CDS, random displaced β-CDS） on solubilization and fluorescence enhancement of curcumin was discussed. The fluorophotometric titration method was used to determine the complex stability constants （K） for the inclusion complexation of curcumin and five cyclodextrins in buffer solution （pH 2）. The results showed that 1 ： 1 inclusion complexation was observed in β-CD with curcumin, while 2 ： 1 and 1 ： 1 inclusion complexations were observed in HP-β-CD and cyclodextrin sulfates with curcumin. HP-β-CD and β-CDS showed better complexation ability, and fluorescence was enhanced by 17 and 19 times in 0.03mol/L concentrations.

关 键 词：姜黄素 Β-环糊精 羟丙基-Β-环糊精 环糊精硫酸酯 增溶 荧光增强 主客体包合 

分 类 号：R284[医药卫生—中药学] O657.3[医药卫生—中医学]