槲皮素-聚乙二醇固体分散体对亚硝化反应的抑制作用  

In vitro Inhibition of Quercetin-polyethylene Glycol Solid Dispersions against Nitroso Reaction

作　　者：吴春[1] 车春波[1] 李俊生[1] 代丽君[2] 

机构地区：[1]哈尔滨商业大学食品工程学院,黑龙江哈尔滨150076 [2]哈尔滨商业大学物流学院,黑龙江哈尔滨150076

出　　处：《食品科学》2008年第3期53-55,共3页Food Science

基　　金：黑龙江省教育厅重点项目(11511Z03)

摘　　要：以槐米为原料制备槲皮素。为改善槲皮素的水溶性,以聚乙二醇为载体,采用熔融法将其制成槲皮素-聚乙二醇固体分散体,使其在水中的溶解度由11.8mg/L提高到80.2mg/L。在模拟人体胃液的条件下,考察该分散体对亚硝化反应的抑制作用。结果表明,槲皮素-聚乙二醇固体分散体对亚硝化反应具有较强的抑制作用,其对亚硝胺合成的最大阻断率达91.3%,对亚硝酸钠的最大清除率为86.1%。The quercetin was prepared from Flos Sophorae Immaturus. To improve the solubility of quercetin in aqueous solution, the solid dispersions of quercetin-polyethyleneglycol were prepared by fusion method so as to increase quercetin as solid dispersion in water from 11.8 μ g/ml to 80.2μg/ml. Under the simulated gastric solution, the nitrosation inhibition was studied. The results showed that the solid dispersions of quercetin-polyethylene glycol have strong effects on disconnecting NDMA and scavenging sodium nitrite. The maximum disconnecting rate of NDMA is 91.3%, and the maximum scavenging rate of sodium nitrite is 86.1%.

关 键 词：槲皮素 聚乙二醇 固体分散体 亚硝化 

分 类 号：R284[医药卫生—中药学]