高糖低脂膳食对健康青年血脂比值的影响  

Effects of High-carbohydrate/Low-fat Diet on Serum Lipid Ratios in Healthy Young Subjects

作　　者：甘婵芬[1] 龚仁蓉[2] 林佳[1] 李正科[1] 汤慧[1] 黄鑫[1] 李蓉辉[1] 方定志[1] 

机构地区：[1]四川大学华西基础医学与法医学院生物化学与分子生物学教研室,成都610041 [2]四川大学华西医院胸心血管外科

出　　处：《四川大学学报（医学版）》2008年第2期267-271,275,共6页Journal of Sichuan University(Medical Sciences)

基　　金：四川省重点科技项目(项目编号:03SG022-002);教育部新世纪优秀人才支持计划(项目编号:NCEF04-0863)资助

摘　　要：目的探讨短期高糖低脂膳食对健康青年血脂比值甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)、log(TG/HDL-C)、总胆固醇(TC)/HDL-C、低密度脂蛋白胆固醇(LDL-C)/HDL-C的影响。方法在校大学生自愿者56名(22.89±1.80)岁,于7 d平衡膳食后给予高糖低脂膳食6 d,分别在第1 d、8 d、14 d清晨抽取空腹静脉血,测定TG、TC、HDL-C、LDL-C浓度,计算TG/HDL-C、log(TG/HDL-C)、TC/HDL-C、LDL-C/HDL-C值。结果高糖低脂膳食后,TG/HDL-C、log(TG/HDL-C)在女性显著升高(P<0.05),男性有下降趋势,但无统计学意义。按BMI或WHR分析发现,高糖低脂膳食后TG/HDL-C、log(TG/HDL-C)在正常女性显著升高(P<0.05),而在一般肥胖或腹型肥胖女性无显著性改变;不同BMI或WHR男性高糖低脂膳食后TG/HDL-C、log(TG/HDL-C)无显著变化。TC/HDL-C、LDL-C/HDL-C在高糖低值膳食后均显著下降(P<0.05),且不受性别、BMI、WHR的影响。结论高糖低脂膳食诱导的TG/HDL-C、log(TG/HDL-C)改变因性别及BMI或WHR不同而不同,TC/HDL-C、LDL-C/HDL-C的改变则不受其影响,对指导相应人群改变膳食结构具有重要意义。Objective To investigate the effects of the short-term high-carbohydrate/low-fat （HC/LF） diet on the serum lipid ratios of healthy young subjects, which meant triglyceride to high-density lipoprotein cholesterol （TG/HDL-C）, the logarithm of TG/HDL-C [log （TG/HDL-C）], low-density lipoprotein cholesterol to highdensity lipoprotein cholesterol （LDL-C/HDL-C）, and total cholesterol to high-density lipoprotein cholesterol （TC/HDL-C）. Methods 56 healthy participants with the average age of （22.89±1.80） years took the normal diet for 7 days followed by HC/LF diet for 6 days. Venous blood samples in fasting were collected between 7 ： 00 and 10 ： 00 AM on the 1st, the 8th and 14th day, respectively. Serum concentrations of triglyceride （TG）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C）, and low density lipoprotein cholesterol （LDL-C） were measured by regular methods. The ratios of TG/HDL-C, log （TG/HDL-C）, LDL-C/HDL-C, and TC/ HDL-C were calculated. Results After HC/LF diet, both TG/HDL-C and log （TG/HDL-C） increased significantly for females （P〈0. 05）. For the males, these.two ratios were decreased although not significant in statistics. When BMI or WHR was taken into account, the two ratios increased significantly after HC/LF diet, but only for the normal females（P〈0. 05）, not for the females with overall or abdominal adiposity. No significant changes of TG/HDL-C and log（TG/HDL-C） after HC/LF diet were observed between the males with different BMI or WHR. TC/HDL-C and LDL-C/HDL-C decreased significantly （P〈0. 05） after HC/LF diet, but these changes were not found to associate with gender, BMI or WHR. Conclusion The changes of TG/HDL-C and log （TG/HDL-C） induced by the short-term HC/LF diet are different in healthy young subjects with different gender, BMI or WHR, but there is no significant change happening to TC/HDL-C and LDL-C/HDL-C.

关 键 词：高糖低脂膳食 血脂比值 健康青年 体重指数 腰臀比 

分 类 号：R151[医药卫生—营养与食品卫生学]