E-cadherin和nm23-H1在胰腺癌的表达及其临床意义  

The expression of E-cadherin and nm23-H1 in pancreatic cancer and its clinical significance

作　　者：杨用武[1] 孙权[1] 彭姣珍[1] 

机构地区：[1]武汉大学中南医院普外科,湖北省监利县人民医院普外科430071

出　　处：《腹部外科》2008年第1期55-56,共2页Journal of Abdominal Surgery

摘　　要：目的探讨上皮细胞钙黏蛋白(E-cadherin)和转移抑制基因(nm23-H1)表达与胰腺癌侵袭转移的关系。方法应用免疫组织化学技术SP法,检测31例癌组织中E-cadherin和nm23-H1的表达水平。结合肿瘤的侵袭转移能力、分化程度和分期等进行分析。结果31例胰腺癌组织中E-cadherin和nm23-H1的表达强度均低于对照的胰腺组织;E-cadherin和nm23-H1的表达强度与胰腺癌的远处转移能力密切相关;胰腺癌中E-cadherin和nm23-H1的表达具有明显正相关。结论E-cadherin和nm23-H1的表达水平能反映胰腺癌的侵袭转移能力。两种蛋白的表达水平之间呈明显正相关。联合检测两种蛋白在胰腺癌组织中的表达,对临床判断胰腺癌的预后可能有一定的意义。Objective To investigate the expression of E-cadherin and nm23-H1 and their correlation with the invasion and metastasis of pancreatic cancer. Methods Immunohistochemical technique was used to detect the expression of E-cadherin and nm23-H1 in 31 cases of pancreatic cancer, 8 normal pancreatic tissues and 7 cases of chronic pancreatitis. Invasion, metastasis and differentiation and staging in pancreatic cancer were analyzed. Results In 31 cases of pancreatic cancer, the expression levels of E-cadherin and nm23-H1 were lower than in the control tissues（P〈0. 05）. The expression intensity of E-cadherin and nm23-H1 was significantly positively correlated with the distant metastasis of pancreatic cancer. In pancreatic cancer, there was a significantly positive correlation between the expression of E-cadherin and nm23-H1. Conclusion The expression of E-cadherin and nm23-H1 can reveal the invasion and metastasis ability of pancreatic cancer. Combined detection of the E-cadherin and nm23-H1 protein expression in pancreatic cancer tissues may play some roles in clinically evaluating the the prognosis of pancreatic cancer.

关 键 词：胰腺肿瘤 肿瘤转移 桥粒钙黏蛋白质类 基因 肿瘤抑制 

分 类 号：R737.9[医药卫生—肿瘤] R735.902[医药卫生—临床医学]