肝细胞癌组织上皮性钙黏蛋白表达及其临床意义的研究  

Relationship between E-Cadherin and invasion and metastasis of hepatocellular carcinoma

作　　者：杨华伟[1] 彭浩[2] 洪坚善[1] 段小娴[3] 曹骥[3] 

机构地区：[1]广西医科大学附属肿瘤医院胃肠乳腺外科,广西南宁530021 [2]北京煤炭总医院普外科,北京100028 [3]广西医科大学附属肿瘤医院基础病理研究室,广西南宁530021

出　　处：《中华肿瘤防治杂志》2008年第2期131-133,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:研究上皮性钙黏蛋白(E-Cad-herin)在人肝细胞癌(hepatocellular carcinoma,HCC)组织中的表达情况,探讨其与肝癌侵袭转移的关系。方法:选择56例有完整随访资料的HCC及相应癌旁组织标本、20例正常肝组织标本,用RT-PCR方法检测E-Cadherin mRNA的表达。结果:E-Cadherin在HCC组织中的表达显著低于癌旁组织和正常组织,P分别为0.016和0.003,而在癌旁组织和正常组织中的表达差异无统计学意义,P分别为0.076和0.082;E-Cadherin在肝癌组织中的表达与术后复发时间呈正相关,R2=0.887,P<0.05,与病理分级呈负相关,R2=0.823,P<0.05;癌组织中E-Cadherin表达与肝外转移呈负相关,R2=0.839,P<0.05。结论:E-Cadherin表达与肝癌的分化程度,侵袭转移能力,复发倾向相关,通过检测E-Cadherin表达将对肝癌临床转归的评估有一定指导意义。OBJECTIVE： To investigate the association between E-Cadherin expression and invasion and metastasis of hepatocellular carcinoma （HCC）. METHODS： RT-PCR analysis technology were used to detect E-Cadherin mRNA expression in 56 paired HCC and non-HCC liver tissue samples and 20 normal liver tissue samples, respectively. RESULTS： The level of E-Cadherin expression in HCC was significantly lower than those in the adjacent non-HCC liver tissue and normal liver tissue （P were 0. 016 and 0.003 respectively）, hut no difference was seen between the adjacent non-HCC liver tissue and normal liver tissue （P were 0. 076 and 0. 082 respectively）. E-Cadherin expression in HCC had a positive correlation with the recurrence after the surgical treatment （R2 =0. 887, P〈0. 05）, and an inverse correlation with pathological grade, R2 =0. 823, P〈0. 05. There was an inverse correlation between E-Cadherin expression and extrahepatic metastasis in HCC, R2 =0. 839, P〈0. 05. CONCLUSION： E-Cadherin has an correlation with the degree of tumor differentiation, capability of invasion and metastasis and tendency of recurrence, which may have some instructive significance for assessment of outcome of HCC.

关 键 词：癌 肝细胞/代谢 癌 肝细胞/病理学 钙粘着糖蛋白类/代谢 肝肿瘤/病理学 肿瘤转移 

分 类 号：R735.7[医药卫生—肿瘤]