H pylori recurrence after successful eradication  

作　　者：Yaron Niv 

机构地区：[1]Department of Gastroenterology, Rabin Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva 49100, Israel

出　　处：《World Journal of Gastroenterology》2008年第10期1477-1478,共2页世界胃肠病学杂志（英文版）

摘　　要：Recurrence of H pylori after eradication is rare in developed countries and more frequent in developing countries. Recrudescence (recolonization of the same strain within 12 mo after eradication) rather than reinfection (colonization with a new strain, more than 12 mo after eradication) is considered to be responsible for most of the cases. This observation was confirmed only in developed countries, while in developing countries a recent meta-analysis demonstrated a high rate of reinfection. The proportion of H pylori annual recurrence was 2.67% and 13.00% in developed and developing countries, respectively. Nested meta-analysis (only cases with a longer follow-up and a negative 13CUBT a year after eradication) revealed annual recurrence rate of 1.45% [relative risk (RR), 0.54] and 12.00% (RR, 0.92) in developed and developing countries, respectively. These findings support the notion that in developed countries many cases of recurrence are due to recrudescence within the first year after eradication, with a 46% drop in the recurrence rate after the first year post eradication, while in developing countries reinfection is more pronounced, and continue at the same rate since eradication. A different approach for follow-up after H pylori eradication is probably needed in patients of developing countries, since reinfection is highly prevalent.Recurrence of H pylori after eradication is rare in developed countries and more frequent in developing countries. Recrudescence （recolonization of the same strain within 12 mo after eradication） rather than reinfection （colonization with a new strain, more than 12 mo after eradication） is considered to be responsible for most of the cases. This observation was confirmed only in developed countries, while in developing countries a recent meta-analysis demonstrated a high rate of reinfection. The proportion of H pylori annual recurrence was 2.67% and 13.00% in developed and developing countries, respectively. Nested meta-analysis （only cases with a longer follow-up and a negative 13CUBT a year after eradication） revealed annual recurrence rate of 1.45% [relative risk （RR）, 0.54] and 12.00% （RR, 0.92） in developed and developing countries, respectively. These findings support the notion that in developed countries many cases of recurrence are due to recrudescence within the first year after eradication, with a 46% drop in the recurrence rate after the first year post eradication, while in developing countries reinfection is more pronounced, and continue at the same rate since eradication. A different approach for follow-up after H pylori eradication is probably needed in patients of developing countries, since reinfection is highly prevalent.

关 键 词：Helicobacter pylori ERADICATION Recurrence Recrudescence REINFECTION 

分 类 号：R57[医药卫生—消化系统]