肠易激综合征患者外周血炎性细胞因子表达失衡的分析  

Analysis on Expression Imbalance of Peripheral Blood Inflammatory Cytokines in Patients with Irritable Bowel Syndrome

作　　者：梁海清[1] 王世和[1] 李延青[2] 王福胜[1] 

机构地区：[1]山东省德州市人民医院消化科,253014 [2]山东大学齐鲁医院消化科

出　　处：《胃肠病学》2008年第2期111-113,共3页Chinese Journal of Gastroenterology

摘　　要：背景:肠易激综合征(IBS)的发病机制不明,炎性细胞因子表达失调可能在其中发挥一定作用。目的:研究IBS患者血浆炎性细胞因子白细胞介素(IL)-6、IL-18、IL-13的表达。方法:选取42例IBS患者和20名对照者,以酶联免疫吸附测定(ELISA)检测血浆IL-6、IL-18、IL-13水平。结果:与对照组相比,腹泻型IBS组血浆IL-6和IL-18水平、便秘型IBS组血浆IL-18水平显著升高(P均<0.05)。腹泻型和便秘型IBS组血浆IL-13水平与对照组相比无显著差异。感染后IBS(pIBS)组血浆IL-6、IL-18水平较对照组显著升高(P<0.05),pIBS组和非pIBS组血浆IL-13水平与对照组相比无显著差异。结论:IBS患者血浆促炎细胞因子水平升高,感染因素影响了腹泻型IBS血浆细胞因子的变化,促炎细胞因子可作为IBS的潜在生物学标记物。Background： The pathogenesis of irritable bowel syndrome （IBS） is not completely clarified. The imbalance of inflammatory cytokines may play some roles. Aims： To study the expressions of peripheral blood inflammatory cytokines interleukin （IL）-6, IL-18, IL-13 in patients with IBS. Methods： Forty-two patients with IBS and 20 controls were enrolled. The expressions of plasma IL-6, IL-18, IL-13 were determined by enzyme-linked immunosorbent assay （ELISA）. Results： Compared with control group, expressions of plasma IL-6, IL-18 in diarrhea-predominant IBS （D-IBS） group and IL-18 in constipation-predominant IBS （C-IBS） group increased significantly （P all 〈0.05）. No significant differences were found in plasma IL-13 level between the two IBS groups and control group. Compared with control group, plasma IL-6, IL-18 levels in postinfeetious IBS （pIBS） group were significantly higher （P〈0.05）. No significant differences were found in expression of plasma IL-13 between pIBS group, non-pIBS group and control group. Conclusions： Levels of plasma proinflammatory cytokines increase in IBS patients. Infection factors can affect the change of plasma cytokines in D-IBS, and proinflammatory cytokines may be used as potential biomarkers for IBS.

关 键 词：肠易激综合征 细胞因子类 白细胞介素类 酶联免疫吸附测定 

分 类 号：R574[医药卫生—消化系统]