共聚物-锌与多肽的相互作用  

Interaction of Copolymer-Zn with Polypeptide

作　　者：赵建新[1] 乔义涛[1] 冯菁[1] 罗昭峰[2] 袁直[1] 

机构地区：[1]南开大学高分子化学研究所,功能高分子材料教育部重点实验室,天津300071 [2]中国科技大学生命科学学院,合肥230027

出　　处：《高等学校化学学报》2008年第3期658-660,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:50573034,20634030)资助

摘　　要：A new copolymer(C) was designed and synthesized.Isothermal Titration Calorimetry(ITC) expe-riments showed the strong binding of C-Zn and the predetermined peptide sequences(DFLAE,appear in many peptides sequence which cumulate in serum of uremic patients).The further ITC experiments demonstrate that the binding is the result of the cooperative effect of coordination and hydrophobic interaction,which may provide further understanding on the mechanism of polymer-metal-peptide interaction and a structural basis for designing the adsorbents for the target peptide.A new copolymer（C） was designed and synthesized. Isothermal Titration Calorimetry（ITC） experiments showed the strong binding of C-Zn and the predetermined peptide sequences（ DFLAE, appear in many peptides sequence which cumulate in serum of uremic patients）. The further ITC experiments demonstrate that the binding is the result of the cooperative effect of coordination and hydrophobic interaction, which may provide further understanding on the mechanism of polymer-metal-peptide interaction and a structural basis for designing the adsorbents for the target peptide.

关 键 词：多肽 共聚物 分子间相互作用 

分 类 号：O632.19[理学—高分子化学]