急性脑梗死缺血半暗带演变的磁共振成像研究  

A Study on Ischemic Penumbra Evolving Process of Acute Cerebral Ischemia by Magnetic Resonance Imaging

作　　者：魏秀娥[1] 荣良群[1] 许静[1] 张涛[1] 朱本亮[1] 龚爱平[1] 高丽[1] 杨森[1] 

机构地区：[1]徐州医学院第二附属医院神经内科,221006

出　　处：《中国临床神经科学》2008年第2期145-148,共4页Chinese Journal of Clinical Neurosciences

基　　金：徐州市科学技术局计划项目(X2005234)

摘　　要：目的:探讨应用磁共振弥散/灌注成像技术判断急性脑梗死后缺血半暗带IP存在的范围和时间规律。方法:对72例发病时间在1～24h的急性脑梗死患者行常规MRI、磁共振弥散加权成像(DWI)和磁共振灌注加权成像(PWI)确定IP的范围,计算梗死中心区、IP区及对侧镜像区的ADC值和rADC值并加以比较。结果:26例发病时间<6h的患者PWI显示存在低灌注区者,其中PWI>DWI者21例,30例发病时间在6～24h的患者PWI显示存在低灌注区者,其中PWI>DWI者2例;PWI>DWI者病灶中心ADC值与IP区及对侧镜像区ADC值差异有统计学意义,其IP区ADC值与其对侧镜像区差异无统计学意义。结论:DWI和PWI结合能灵敏的判断IP的存在,IP存在的时间窗有一定的个体差异。Aim ： To explore the size and time process of ischemic penumbra of acute cerebral ischemia with diffusion/perfusion weighted magnetic imaging. Methods： 72 patients with acute cerebral infarction within 1-24 hours after onset of clinical symptoms were underwent conventional MRI and diffusion/perfusion weighted magnetic imaging to identify the size of ischemic penumbra, ADC and rADC in the infarct area and ischemic penumbra in the affected hemisphere and the counterpart in the contralateral hemisphere were calculated and compared. Results： PWI demonstrated regional cerebral blood flow reduction in 26 patients within 6 hours and 30 patients within 6-24 hours after onset, PWI〉DWI in 21 cases among patients within 1-6 hours and 4 cases among patients within 6-24 hours. If PWI〉DWI, there was significant difference between the ADC value in the infarct area and ischemic penumbra in the affected hemisphere and the counterpart in the contralateral hemisphere. Conclusion ： DWI and PWI can sensitively detect ischemic penumbra, the duration of ischemic penumbra has individual differences.

关 键 词：脑梗死 磁共振成像 缺血半暗带 

分 类 号：R743[医药卫生—神经病学与精神病学]