Ⅲ期食管癌术后同期放化疗的疗效观察  

Curative Effect of Chemoradiotherapy on Postoperative Patients with stage Ⅲ Esophageal Carcinoma

作　　者：关春文[1] 田梅玲[1] 胡永强[1] 

机构地区：[1]濮阳市人民医院放疗科,河南濮阳457000

出　　处：《医学综述》2008年第5期793-794,共2页Medical Recapitulate

摘　　要：目的比较食管癌术后Ⅲ期同期放化疗和放疗的远期效果及毒性反应,探索食管癌术后Ⅲ期治疗的新途径。方法将56例食管癌术后Ⅲ期患者随机分成放疗和同期放化疗组,每组各28例,2组放疗均采用常规分割放射治疗,化疗采用顺铂、5-氟尿嘧啶方案。同期放化疗组从放射治疗第1日起给予化疗,以后每隔27d化疗1周期,每例患者化疗时间不少于4周期。结果同期放化疗组1、2和3年生存率分别为59.1%、46.5%和39.8%;单纯放疗组的1、2和3年生存率分别为59.2%、40.1%和14.2%。严重毒性反应:同期放化疗明显高于单纯放疗。结论同期放化疗对食管癌术后Ⅲ期治疗价值具有协同作用,可提高食管癌术后Ⅲ期患者的3年生存率,但急性放射性损伤的发生率也有明显提高。Objective To compare long-term effects and toxieities of single treatment with randiotherapy and the combined treatment with chemotherapy and radiotherapy on postoperative patients with stage Ⅲ esophageal eareinoma.Methods Fifty-six postoperative patients with stage Ⅲ esophageal carcinoma, at were randomly divided into radiotherapy group（28 cases） and ehemoradiotherapy group（28 ease）. Both groups were treated by the conventional dissection radiotherapy. 5-fluorouraeil were used in the ehemoradiotherapy group by venous infusion and cisplatin as well as synehronal radiotherapy. One phase consisted of 28 days and each patient received more than 4 phases of chemotherapy. Results The one year, two-year and three-year survival rate for patients in ehemoradiotherapy group were 59.1%,46.5 %, 39.8 %, respectively, and those were 59.2%, 40.1%, 14.2% in single radiotherapy guoup, respectively. Toxicity for patients in ehemoradiothempy group was more severe than patients with single radiotherapy treatment. Conclusions Chemoradiotherapy had synergistic effects in treatment of postoperative patients with stage Ⅲ esophageal eareinoma.The present study demonsmted that the three-year survival rate for ehemoradiotherapy be promising at the cost of much more toxicity,which should be studed furtherly.

关 键 词：食管癌术后Ⅲ期 放射治疗 化学治疗 

分 类 号：R735.1[医药卫生—肿瘤]