c-myc在食管鳞癌、肺鳞癌、胃腺癌组织中的表达及对比分析  

Expression and comparison of c-myc in esophago squamous cartinoma, lung squamous cartinoma, gastric gland carcinoma tissues

作　　者：张建伟[1] 张俊权[1] 王建军[1] 李万刚[1] 单保恩[2] 

机构地区：[1]中国石油天然气集团公司中心医院胸外科,河北省廊坊市065000 [2]河北医科大学第四医院肿瘤研究所病理教研室

出　　处：《中国综合临床》2008年第3期213-214,共2页Clinical Medicine of China

基　　金：河北省科研立项课题（20061109001）

摘　　要：目的研究原发于食管鳞状上皮的食管鳞癌和由肺纤毛柱状上皮化生的肺鳞癌中c—mye的表达是否存在差异，同时比较食管鳞癌、肺鳞癌和胃腺癌组织中c—mye表达的差异，初步分析不同组织来源的癌细胞中c—mye表达差异。方法采用链霉素抗生物素-过氧化物酶（SP）法进行免疫组化染色，检测c—mye在食管鳞癌、肺鳞癌和胃腺癌组织中的表达。结果c-mye在食管鳞癌组织中的阳性表达率为67．4％，在肺鳞癌组织中阳性表达率为73．3％，均明显高于在胃腺癌组织中阳性表达率（42．9％），差异有统计学意冀（均P〈0．05）。结论食管鳞癌和肺鳞癌虽然组织来源不同，但有共同的组织学基础，表述有其共性。c-mye在鳞癌组织中的阳性表达率高于腺癌，这种差异可能与组织特异性表达有关。Objective To detect the expression of c-myc in esophago squamous cartinoma,gastric gland carcinoma and lung sc tissues,to analyze the difference of the expression of c-myc between esophago squamous cell carcinoma and lung squamous cell cancer, at the same time,to analyze the difference between squamous cell carcinoma and gland carcinoma. Methods c-myc was detected by using the method of streptanidin peroxidase（S-P）. Resuits The positive expression rates of c-myc were 67.4% in esophago sc,73.3% in lung sc,42.9% in gastric gland carcinoma （ P 〈 0.05）. Conclusion The positive rate of the expression of c-myc in esophago squamous cell carcinoma,lung squamous cell cancer has no difference though they are from different tissues. They have collective histological foundation,so the expression has something in common. The positive rate of the expression of c-myc in squamous cell carcinoma is higher obviously than gland carcinoma. This difference might be related to the specific expression of tissue.

关 键 词：食管鳞癌 肺鳞癌 胃腺癌 c—mye 免疫组化 

分 类 号：R735.1[医药卫生—肿瘤]