生姜与辣椒提取物联合抗呕吐作用研究  

Antiemetic Effect of the Combination Treatment of Extracts of Capsicum and Gingers

作　　者：王心慧[1] 杨志宏[1] 赵德雪[1] 韩豫恩[1] 岳旺[1] 

机构地区：[1]青岛大学医学院药学系,266021

出　　处：《医药导报》2008年第3期274-277,共4页Herald of Medicine

摘　　要：目的研究生姜及辣椒提取物联合应用对大鼠止呕效果。方法将大鼠随机分组,分别给予顺铂、阿朴吗啡及旋转刺激,并设立对照,测定大鼠异嗜高岭土的量,观察对成功建立的大鼠异嗜呕吐模型的联合止呕效果。结果顺铂(3 mg.kg-1,ip),阿朴吗啡(3.2 mg.kg-1,sc)以及旋转(100 r.min-1,1 h)均能引起大鼠的异嗜呕吐行为,可观察到生姜及辣椒提取物两个剂量组可抑制顺铂、阿朴吗啡、旋转所致的大鼠异嗜高岭土的量(P<0.05),并呈现一定的量效关系。结论生姜及辣椒提取物对大鼠异嗜呕吐模型具有协同止呕作用,且可以降低辣椒单独应用时对胃肠道的刺激,其机制可能与P物质、5-HT3受体及抑制呕吐中枢有关。Objective To study the cooperative antiemetic effects of extracts of capsicum and gingers in rats. Methods The rats were randomly divided into 4 groups and respectively administrated with cisplatin, apomorphine, rotation,or distilled water as the control. The consumption of nonnutritive kaolin was recorded in rats. The antiemetic effect of combined capsicum with gingers was observed in the emetic animal model. Results The emetic behaviors of pica could be successfully induced by cisplatin（3 mg·kg^-1,ip）, apomorphine （3.2 mg·kg^-1, sc） and rotation （100 r·min^-1, 1h）. Cooperatively given extracts of capsicum and gingers in two groups could markedly inhibit kaolin intakes induced hy cisplatin, apomorphine and rotation in a dose-dependent manner （P〈0.05）. Conclusions The combination of extracts of capsicum and gingers showed an antiemetic effect in model rats, and gingers might decrease the gastrointestinal stimulus resulted from capsicum treatment alone. The mechanism may be the inhibitions of substance P ,5-HT3 acceptors and the vomiting center in central nervous system.

关 键 词：辣椒提取物 生姜提取物 呕吐 P物质 5-羟色胺 大鼠 

分 类 号：R975.4[医药卫生—药品] R285.5[医药卫生—药学]