肿瘤休眠与血管新生  

Recent Advances in Our Understanding of Angiogenesis and Tumor Dormancy

作　　者：张瑜[1] 车国卫[1] 

机构地区：[1]四川大学华西医院胸心外科,成都市610041

出　　处：《中国肿瘤临床》2008年第5期293-296,共4页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金资助(编号:30400199)

摘　　要：肿瘤休眠是指肿瘤细胞在宿主体内持续存在而没有明显生长的一种状态,存在复发和转移的可能性,是恶性肿瘤难以彻底根治的根源之一。现在研究表明血管新生与肿瘤演进密切相关。本文从血管新生与肿瘤休眠的关系,肿瘤休眠模型的建立,肿瘤休眠的研究方法,休眠标志物的检测等方面进行了论述。旨在为阐明血管生成与肿瘤休眠的关系,以及临床应用抗血管生成疗法治疗肿瘤提供有益的线索。Tumor dormancy, a complex and still poorly understood phenomenon observed both in experimental models and in patients, has been defined by the long-term persistence of occult cancer cells during tumor progression. Recurrence and metastasis may occur because of this small population of tumor cells. Sustained angiogenesis is considered essential in triggering invasive tumor growth. Here we discuss the correlation between angiugenesis and tumor dormancy, the establishment of tumor dormancy models and new biomarkers for detecting microscopic tumors before or during the angiogenie switch. The imaging techniques and the different strategies for isolation of both angiogenie and non-angiogenic tumor cell populations are also summarized. To eradicate dormant disease, it is imperative to understand the role of anglogenesis in tumor dormancy.

关 键 词：肿瘤休眠 血管新生表型 肿瘤休眠疗法 

分 类 号：R730.2[医药卫生—肿瘤] R730.5[医药卫生—临床医学]