1-苯基-3-羧酸乙酯-5-吡唑啉酮的合成  

Synthesis of 1-Phenyl-3-carbethoxy-5-pyrazolone

作　　者：舒燕[1] 于秀兰[1] 孔祥文[1] 杨桂秋[1] 

机构地区：[1]沈阳化工学院应用化学系,沈阳110021

出　　处：《染料与染色》2008年第1期36-37,共2页Dyestuffs and Coloration

摘　　要：以乙酸乙酯和草酸二乙酯为原料,经交叉Claisen酯缩合反应合成2-氧代丁二酸二乙酯钠盐,用此盐与苯肼在酸性条件下进行加成缩合反应制得苯腙,再经闭环、酸化可制得1-苯基-3-羧酸乙酯-5-吡唑啉酮。产物的结构经红外光谱和核磁共振谱确认合格。Sodium diethyl oxalacetate was prepared by Claisen condensation of diethyl oxalate with ethyl acetate. It condensed with phenyl hydrazine in the acid condition, and then cyclizated and acidified to prepare 1-phenyl-3-carbethoxy-5-pyrazolone. The structure of product was identified by IR and ^1 H-NMR.

关 键 词：Claisen酯缩合 2-氧代丁二酸二乙酯钠盐 合成 1-苯基-3-羧酸乙酯-5-吡唑啉酮 

分 类 号：TQ252[化学工程—有机化工]