电阻抗断层成像技术对小猪蛛网膜下腔出血早期监护作用的初步研究  

Early monitoring of electrical impedance tomography in subarachnoid hemorrhage piglet models

作　　者：李连峰[1] 徐灿华[2] 赵振伟[1] 王樑[1] 史学涛[2] 游宇[1] 李维新[1] 董秀珍[2] 高国栋[1] 

机构地区：[1]第四军医大学唐都医院神经外科,西安710038 [2]第四军医大学生物医学工程系,西安710032

出　　处：《中华神经医学杂志》2008年第3期278-281,共4页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金（50337020）

摘　　要：目的观察实验性蛛网膜下腔出血时脑部生物电阻抗断层（EIT）成像的变化规律．探讨其机制及临床应用价值。方法采用枕大池单次注血模型模拟自发性蛛网膜下腔出血，应用脑EIT成像系统进行连续动态监护，得出蛛网膜下腔出血后脑EIT成像的动态变化。结果成功建立模型8例，EIT监护图像变化显示注血早期颅脑前部阻抗降低明显，后部电阻抗轻度降低：注射结束后全脑电阻抗逐渐升高，颅脑后部增高明显。结论脑EIT成像对实验性蛛网膜下腔出血后的电阻抗变化具有敏感性，并对出血部位有一定的定位作用，具有一定的临床应用价值。Objective To investigate the value of electrical impedance tomography （EIT） system in the early diagnosis of subarachnoid hemorrhage （SAH） through observing the primary regularity of the electrical impedance changes in SAH animal models as well as the possible mechanism of this regularity. Methods The experimental SAH models in piglets were introduced by one-time injection of fresh autologous blood into the cistema magna. We observed the changes of the two-dimensional imaging with EIT system used for continual dynamic monitoring to the models. Results The models were successfully introduced in 8 piglets. In the forepart of the injection, resistivity configuration decreased at the anterior region of the head as well as the posterior of that. At the time of finishing injection, the resistivity configuration reached the negative max value. After injection, resistivity configuration at the anterior region of the head gradually came back. But the resistivity configuration at the posterior region of the head increased persistently. Conclusions Although the configuration of human head is so complex that limits the application of EIT on the head, it does have certain sensitivity in the diagnosis of SAH and can localize the hemorrhage site, so EIT may be applied widely in early diagnosis and assistant treatment of SAH in clinical.

关 键 词：蛛网膜下腔出血 电阻抗成像 生物电阻抗 动物模型 监护 

分 类 号：R743.35[医药卫生—神经病学与精神病学]