检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
机构地区:[1]青岛大学医学院附属青岛市市立医院病理科,山东青岛266011
出 处:《齐鲁医学杂志》2008年第1期1-2,共2页Medical Journal of Qilu
基 金:青岛市科技局基金资助项目(03-1-NY-14-2)
摘 要:目的应用组织芯片(TMA)技术检测Survivin在肝细胞肝癌(HCC)组织中的表达及其与Ki67的关系。方法应用组织芯片技术检测Survivin、Ki67在76例肝癌组织、53例癌旁组织中的表达。结果肝癌组织中Survivin的表达明显高于其在癌旁组织中的表达(2χ=129,P<0.05);Survivin的表达与癌组织的分化程度无相关关系(P>0.05);Survivin与Ki67的表达呈正相关关系(r=0.969,P<0.05)。结论Survivin和Ki67可能与肝细胞癌的发生发展有关,两者协同在肝癌的发生发展中发挥作用;两者检测对判定肝细胞癌的病因及预后可能具有参考价值。Objective To detect the expression of Survivin and analyze its relationship with Ki67 in hepatoma by tissue microarray (TMA). Methods Using TMA technique, the expression of Survivin and Ki67 in 76 cancer tissues, and 53 paraneo plastic were determined. Results Expression of Survivin was higher in cancer cells than in paraneoplastic tissue (x^2 = 129, P〈 0.05), a positive correlation existed between Survivin and Ki67 (r= 0. 969, P〈0.05). No correlativity was found between Survivin and histodifferentiation of the cancer (P〉0.05). Conclusion Survivin and Ki67 might be related with the occurrence and development of liver cell carcinoma, the detection of them is likely of reference value in assessment of the etiology and prognosis of the disease.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.222