5-氟尿嘧啶间质化疗治疗胰腺癌的药动学研究  

Pharmacokinetical study of 5-Fluorouracil based interstitial chemotherapy in pancreatic cancer

作　　者：李井泉[1] 赵平[1] 王世亮[2] 史仲华[1] 王成锋[1] 单毅[1] 赵东兵[1] 吴铁成[1] 张育荣[1] 

机构地区：[1]中国医学科学院·中国协和医科大学肿瘤医院肿瘤研究所,北京100021 [2]合肥工业大学控释药物研究室,安徽合肥230009

出　　处：《中国药理学通报》2008年第3期387-390,共4页Chinese Pharmacological Bulletin

基　　金：国家科技十五攻关计划资助课题(No2004BA703B11)

摘　　要：目的研究5-氟尿嘧啶间质化疗治疗胰腺癌的药代动力学特点。方法45名胰腺癌患者随机分为3组,分别给以间质化疗、介入化疗、全身化疗。结果间质化疗与全身化疗、介入化疗相比较,药物代谢的半衰期延长、表观分布容积增大,曲线下面积减小。结论间质化疗具有独特的药代动力学方面的优势,能够延长药物在局部的作用时间,提高局部的药物浓度。Aim To study the pharmacokinetics of 5- Fluorouracil based interstitial chemotherapy in pancreatic cancer. Methods 45 pancreatic cancer patients were randomly divided into three groups, receiving interstitial chemotherapy, interventional chemotherapy and systematic chemotherapy respectively. Results Interstitial chemotherapy has a high apparent volume of distribution, long half time and small area under the curve compared with systematic chemotherapy and interventional chemotherapy. Conclusions Interstitial chemotherapy can prolong the regional action time and improve the regional concentration of chemotherapeutic drugs.

关 键 词：间质化疗 药代动力学 胰腺癌 

分 类 号：R735.905.3[医药卫生—肿瘤] R969.1[医药卫生—临床医学]