pH对HSA-IFNα 2β稳定性的影响  

Effect of pH on stability of HSA-IFN α 2β

作　　者：林斌[1] 刘龙孝[1] 马国昌[2] 黄岩山[3] 周金宝[2] 

机构地区：[1]浙江大学药学院,杭州310058 [2]杭州九源基因工程有限公司,杭州310018 [3]浙江大学医学院,杭州310058

出　　处：《海峡药学》2008年第2期13-14,共2页Strait Pharmaceutical Journal

摘　　要：目的考察不同pH值对一类新药HSA-IFNα 2β稳定性的影响。方法采用SDS-PAGE电泳法测定溶液中HSA-IFN α2β的纯度,研究了不同pH值对HSA-IFNα 2β稳定性作用。方法HSA-IFNα 2β在pH6.5(10mmol)的磷酸缓冲体系中相对最稳定。OBJECTIVE To study the effect of pH on the stability of HSA-IFN a 2β formulation. METHOD SDS-PAGE electrophoresis method was established for determining the purity of the HSA-IFN a 2β solution, the effect of different pH value on the stability of HAS-IFN a 2β solution was studied. RESULT HSA-IFN a 2β aqueous solution was relatively stable at the phosphoric acid buffered system at PH6.5（10Mmol）.

关 键 词：IFN a 2β PH HSA 

分 类 号：R927.11[医药卫生—药学]