急性脑梗死患者血清IL-6含量和周围血WBC计数的相关研究  

A Study of the Relation between the Serum Levels of IL-6 and the Number of Leukocytes of in Peripheral Blood of the Patients with Acute Cerebral Infarction

作　　者：刘丹[1] 杨巧莲[1] 薛刚[1] 

机构地区：[1]包头医学院第一附属医院神经内科,内蒙古包头014010

出　　处：《包头医学院学报》2008年第1期11-14,共4页Journal of Baotou Medical College

基　　金：包头市科委项目(2001-28)

摘　　要：目的:研究急性脑梗死患者血清I L-6含量和周围血WBC计数的动态变化及二者的相关性。方法:采用双抗体夹心ELISA法对30例急性脑梗死患者,分别在卒中后1天、3天、7天、14天进行连续检测血清IL-6和周围血WBC计数,并与30例健康人作对照。结果:与正常对照组比较,在病程1天、3天、7天3个时间点上血清IL-6水平和周围血WBC计数均增高(P<0.05),血清IL-6在病程第1天明显升高且达到高峰(P<0.05),周围血WBC计数以病程第3天升高最明显并达到高峰(P<0.05),二者与梗死面积大小、神经功能受损程度呈正相关(P<0.05),且二者之间显著相关(r=0.4,P<0.05)。结论:脑梗死伴发炎症反应,炎症反应参与缺血性脑损伤,WBC、IL-6在此过程中起重要作用,且二者成正相关。IL-6是介导炎性反应的细胞因子,起免疫调节作用。如何阻断炎症反应过程,将是研究脑梗死保护治疗的新的有效途径。Objective：To investigate the changes in the serum levels of IL - 6 and the number of leukocytes in peripheral blood of the patients with acute cerebral infarction and their correlation to each other. Methods： By using ELISA, we serially measured the serum levels of IL - 6 and counted the number of leukocytes in peripheral blood of 30 patients with acute cerebral infare - tion at day 1 ,day 2 ,day 7 and day 14. The measure ＇was also taken in 30 normal controls to make a comparison. Results ： At day 1, day 3, day 7, the level of IL -6 and the number of leukocytes in both patient groups were significantly higher than those in the eontrols（P 〈0.05）.The IL-6 levels got to the peak at day 1（ P 〈0.05） and the leukocyte number got to the peak at day 3 （ P 〈 0.05 ）. Both of them were positively correlated with the infart sizes and defect degree in neural function（ P 〈 0.05 ）, and the IL - 6 level was correlated with the leukocyte number in acute cerebral infarction （ r = 0.4, P 〈 0.05 ）. Conclusion： Inflare - matory reaction associated with the acute cerebral infarction, takes place in the process of isehemie brain damage. Leukocyte and IL - 6 play an important role in the process, and both of them are positively correlated to each other. IL - 6 is a mediating inflammatory eytokine, and it takes part in the im - mune regulation. How to cut down the processing of inflammatory reac - tion will be the new effective way to study the protective therapy for cerebral infarction.

关 键 词：脑梗死 IL-6 白细胞 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R581.1[医药卫生—临床医学]