肝癌死亡率显著差异地区肝癌病例HBV标记对比  

THE COMPARISON OF THE INFECTION CHARACTERISTICS OF PATIENTS WITH HCC IN TWO AREAS WITH SIGNIFICANT DIFFERENCE OF MORTALITY OF HCC

作　　者：余万霰[1] 张永虹[2] 余奇[3] 张宝初[4] 吴磊[5] 

机构地区：[1]南昌大学医学实验部预防医学中心实验室,南昌330006 [2]南昌大学第二附属医院检验科 [3]南昌大学第一附属医院院内感染管理科 [4]江苏省启东市肝癌防治研究所 [5]南昌大学公共卫生学院

出　　处：《现代预防医学》2008年第6期1004-1006,共3页Modern Preventive Medicine

基　　金：国家自然科学基金项目(39360030,39860030)

摘　　要：[目的]随着病毒环境基因组研究的进展,已发现HBV基因组序列存在明显地理差异,本研究对我国肝癌死亡率最高地区之一的江苏省启东市和肝癌死亡率一般性地区之一的江西省南昌市的生活原地肝癌病例的HBV感染免疫学标记进行对比分析,从HBV感染机制上探索我国肝癌死亡率具有显著差异的原因,为我国HBV并肝癌的遗传性环境基因组研究开拓思路。[方法]选择启东与南昌生活原地的肝癌病例,采集HBV感染免疫学标记(HBsAg、抗-HBs、HBeAg、抗-Hbe、抗-HBc)阳性数据,随机输入SPSS10、0软件程序,排列出感染模式,用卡方检验方法对两地区模式标记及单项标记进行对照性统计学分析。[结果]南昌高于启东的模式有:I型HBsAg(+)、HBeAg(+)抗-HBc(+),Ⅱ型HBsAg(+)、抗-HBe(+)、抗-HBc(+)及Ⅲ型HBsAg(+)、抗-HBc(+)。启东高于南昌的模式有:IV型HBsAg(+)、HBeAg(+),V型抗-HBe(+)抗-HBc(+)及VI型抗-HBc(+),均P﹤0.05。5项免疫标记单列进行比较统计,HBsAg(+)存在统计学差异(P﹤0.05),南昌高于启东。[结论]南昌与启东肝癌病例的HBV感染模式存在明显差异,关键是启东肝癌病例HBsAg表达率极低。[Objective]Significant difference on the sequence of HBV gene in difference areas was found with the progression of research on virus-environment genome. This study is to compare and analyze the indexes of HBV infection immunity of patients with HCC in Nanchang with the generality incidence and Qidong with the highest incidence,and to explore the reason that the incidences of HCC have significant difference in our country from the HBV infective mechanism,so as to provide basis for researching on the heritage environment genome of HBV and HCC.[Methods]Patients with HCC in Qidong and Nanchang were selected,and their positive data of HBV infection immunity indexes（HBsAg、anti-HBs、HBeAg、anti-Hbe、anti-HBc）were collected to analyze by SPSS 10.0. The infective mode was arranged. Chi-square test was performed to analyze the labels of the mode the two areas and single labels.[Results]The models of Nanchang higher than Qidong included：Type I：HBsAg（＋）,HBeAg（＋）and anti-HBc（＋）;Type Ⅱ：HBsAg（＋）,anti-HBe（＋）,and anti-HBc（＋）;Type Ⅲ：HBsAg（＋）,anti-HBc（＋）. The models of Qidong higher than Nanchang included：Type IV：HBsAg（＋）and HBeAg（＋）;Type V：anti-HBe（＋）and anti-HBc（＋）;Type VI：anti-HBc（＋）（P﹤0.05）. Five immunity indexes were analyzed by each index,HBsAg（＋）has significant different（P﹤0.05）,and the HBsAg（＋）of Nanchang was higher than that of Qidong.[Conclusion]The infective mode of HBV in patients with HCC showed significant difference between Nanchang and Qidong,the key point is that the expression rate of HBsAg（＋）in Qidong HCC cases showed to be low.

关 键 词：肝癌 HBV 感染标记 自然环境差异 生活原地 

分 类 号：R735.7[医药卫生—肿瘤]