平喘镇咳类中成药中非法添加4种化学药品检验方法的研究  

Identification Method of Four Chemicals in Antiasthmatic and Antitussive Chinese Patent Medicine

作　　者：李莉[1] 张钢平[1] 李晓敏[1] 毕雪艳 赵作连[1] 王志刚[1] 

机构地区：[1]河北邯郸市药品检验所,邯郸市056001

出　　处：《中国药房》2008年第9期676-678,共3页China Pharmacy

基　　金：河北省科技攻关计划项目(06276423)

摘　　要：目的:研究平喘镇咳类中成药中非法添加盐酸麻黄碱、醋酸泼尼松、磷酸可待因、醋酸地塞米松4种化学药品的检验方法。方法:以镇咳药咳宁胶囊为阳性对照,采用高效液相色谱法检测加入的化学药品,以十八烷基硅烷键合硅胶为填充剂。结果:在不同的色谱条件下,4种化学药品均可被检出。结论:本方法简便、实用、专属性强,可用于检验平喘镇咳类中成药中非法添加的化学药品。OBJECTIVE： To establish a method for the identification of four chemicals - Ephedrina Hydrochloridum, prednisone acetate, codeine phosphate and dexamethasone acetate in antiasthmatic and antitussive Chinese patent medicine. METHODS： With Kening capsule（an antitussive） as positive control, the chemicals which were illegally added into the anti- asthmatic and antitussive Chinese patent medicine were determined by HPLC with octadecylsilane chemically bonded silica as loading agent. RESULTS： Under the same chromatographic condition, the four chemicals could all be detected. CONCLUSION： The method is simple, practical and specific, and it can be applied to detect the illegally added chemicals in antiasthmatic and antitussive Chinese patent medicine.

关 键 词：平喘镇咳 中成药 化学药品 高效液相色谱法 检验 

分 类 号：R283[医药卫生—中药学] R927.1[医药卫生—中医学]