荜茇宁降血脂和急性毒性实验研究  

Study on antihyperlipidemia effect and acute toxicity test of piperlonguminine

作　　者：麻春杰[1] 博日吉汗格日勒图 呼日乐巴根[1] 苏日娜[1] 特格希[1] 

机构地区：[1]内蒙古大学高分子化学及蒙药研究所

出　　处：《中华中医药杂志》2008年第4期321-324,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金课题(No.30160103)

摘　　要：目的:研究荜茇宁对动物血脂的影响及急性毒性作用。方法:以大鼠食饵性高脂血症为模型,给予高脂饲料的同时灌服荜茇宁,连续14d,测定血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)含量;采用高脂饲料喂养建立家兔高脂血症模型,观察荜茇宁对血脂、肝脏脂质和动脉粥样硬化的改善情况.通过小鼠急性毒性实验观察其对小鼠产生的毒性反应。结果:荜茇宁显著降低大鼠血清TC、TG、LDL-c和动脉硬化指数(AI),升高HDL-c的含量;能降低家兔血清TC、TG、LDL-c和肝脏TC、TG,并且显著改善动脉粥样硬化。小鼠急性限量毒性实验显示,给药后小鼠未出现死亡及毒性反应。结论:荜茇宁具有明显地降血脂和改善动脉粥样硬化作用,而且毒性极低。Objective： To investigate the influence of piperlonguminine on blood-fat of animal and its acute toxicity. Methods： The hyperlipidemic model rats were established by feeding with the high-lipid diet for 14 days. Stomach-perfusion with piperlonguminine was accompanied at the same time.Effects of piperlonguminine on the hyperlipidemic rats were investigated by measurement of the contents of total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-c）, high-density lipoprotein cholesterol （HDL-c）. The hyperlipidemic model rabbits were established by feeding with hypercholesterol. The influences of piperlonguminine on serum lipid, liver lipid and atheroma were observed. The response of the acute toxicity of mice was also observed. Results ： Piperlonguminine remarkably lowered the serum TC, TG, LDL-c, and increased the serum HDL-c of rats, lowered the serum TC, TG, LDL-c and liver TC, TG, and remarkably improved atheroma of rabbits. The acute toxicity was tested on mice. During the test there was no death. Even more it caused little pathological change. Conclusion： Piperlonguminine not only had significant antihyperlipidemia effects, but also improved atheroma effects. And the toxicity of piperlonguminine was very low.

关 键 词：荜茇 荜茇宁 降血脂 急性毒性 实验研究 

分 类 号：R285.5[医药卫生—中药学]