新型肝靶向一氧化氮供体药物对肝硬化门静脉高压血流动力学的实验性研究  

Effect of a liver-specific nitric oxide donor on hemodynamics of portal hypertension rats

作　　者：汲宏磊[1] 牛俊奇[1] 姜艳芳[1] 于雷[1] 

机构地区：[1]吉林大学第一医院感染科,吉林长春130021

出　　处：《中国实验诊断学》2008年第3期318-320,共3页Chinese Journal of Laboratory Diagnosis

基　　金：国家863计划资助课题课题号:2006AA02Z4C6

摘　　要：目的探讨新型肝靶向一氧化氮(NO)供体药物I1对门静脉血流动力学的影响。方法用四氯化碳(CCl4)复合致病因子复制60只Wistar大鼠肝硬化模型,大鼠随机均分为4组:空白模型对照组,熊去氧胆酸(UDCA)对照组,NCX1000组,I1组。3个药物组分别给予15 mg.kg-1.d-1加入1%羧甲基纤维素悬浮灌胃,空白模型组采用等量1%羧甲基纤维素灌胃对照。分别于给药结束后检测门静脉血流量、肠系膜上静脉血流量、门静脉压力、腹主动脉压。结果与空白模型对照组和熊去氧胆酸组比较,NCX1 000组,I1组的门静脉压力、门静脉血流量、肠系膜上静脉血流量、腹主动脉压力均呈梯度性降低(P<0.05),I1组较NCX1000组上述指标下降明显(P<0.05)。结论新型肝靶向一氧化氮供体药物I1能降低门静脉血流量和门静脉压力,并且不改变体循环压力,较NCX1 000效果更为明确。Objective o investigate the effect of a liver-specific nitric oxide donor on hemodynamics of portal hypertensive rats. Methods 60 Wistar rat models with portal hypertension were induced by CCl4. The rats were divided at random into 4 groups： UDCA group, NCX1000 group, I1 group, and control group. After administration, the blood flow of vena portae, superior mesentefic vein and pressure of vena portae, average arterial pressure were measured. Results Compared with the control group and UCDA group, the blood flow of vena portae, superior mesenteric vein and pressure of vena portae, in NCX1000 and I1 groups were decreased significantly （ P 〈 0.05）, but between NCX1000 group and I1 group, there were also significant differences （ P 〈 0.05）. Conclusion I1 can decrease the blood flow and portal pressure, which suggest it can be employed for treating portal hypertension.

关 键 词：肝靶向治疗 门静脉高压 血流动力学 

分 类 号：R575.2[医药卫生—消化系统]