PPAR在结直肠癌中的表达及意义  

Different expression and significance of peroxisome proliferator-activated receptor γ in colorectal cancer

作　　者：舒振波[1] 操海萍[2] 盖宝东[1] 王巍[1] 

机构地区：[1]吉林大学中日联谊医院胃肠外科,吉林长春130033 [2]吉林大学中日联谊医院泌尿外科,吉林长春130033

出　　处：《中国实验诊断学》2008年第3期327-329,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的观察过氧化物酶体增殖激活物受体(PPAR-γ)在结直肠癌中的表达,探讨其意义。方法采用免疫组织化学方法检测38例结直肠癌及20例癌旁相对正常结直肠组织中PPAR-γ蛋白的表达,并进一步分析PPAR-γ蛋白在不同结直肠癌病理组织类型中的表达。结果PPAR-γ在结直肠癌中表达阳性率为63.16%(24/38),在相对正常结直肠组织中表达阳性率为30.00%(6/20),PPAR-γ在结直肠癌中表达阳性率明显高于癌旁相对正常结直肠组织(P<0.05)。未发现PPAR-γ蛋白表达与结直肠癌病理组织类型相关。结论PPAR-γ蛋白在结直肠癌组织中高表达,提示PPAR-γ可能是结直肠癌发生的一个分子标志。Objective To investigate the expression of peroxisome proliferator-actived receptor γ（ PPAR-γ） in colorectal cancer and to evaluate its possible significance. Methods Immunohistochemistry was used to detect the expression of PPAR-γ in 38 cases of colorectal cancer and 20 cases of relative normal control. The relationship between the expression of PPAR-γ protein and different pathological types of colorectal cancer was analyzed. Results The positive rate of PPAR-γ in colorectal cancer and relative normal control was 63.16%（24/38） and 30.00%（6/20）respectively. The expression of PPAR-γ protein in colorectal cancers was significandy increased（P 〈 0.05）. It was not found thant the expression of PPAR-γ was associated with the pathological types of colorectal cancers. Conclusion The expression PPAR-T protein increased in colorectal cancer, It may be a molicular marker in colorectal cancer.

关 键 词：PPAR-Γ 结直肠癌 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]