多肿瘤标志物蛋白芯片技术在肺癌诊断中的应用  

Application of Multi-Tumor Markers Protein Chip Diagnosis System in Diagnosing Lung Cancer

作　　者：黄建宏[1] 林心[1] 欧兴义[1] 梁小兵[1] 

机构地区：[1]珠海市人民医院,广东珠海519000

出　　处：《实用医技杂志》2007年第36期4943-4945,共3页Journal of Practical Medical Techniques

摘　　要：目的:探讨多肿瘤标志物蛋白芯片技术在肺癌诊断中的应用价值。方法:采用多肿瘤标志物蛋白芯片诊断系统检测30例肺癌、50例良性肺部疾病患者和40例健康体检者的12种常见肿瘤标志物。结果:肺癌组糖抗原(CA)中CA125、CA153、CA242,癌胚抗原(CEA)和铁蛋白(FER)值较其他两组明显升高(P<0.01);联合检测灵敏度80%,灵敏度较单指标检测提高约30%。结论:应用多肿瘤标志物蛋白芯片技术确定CA125、CA242、CA153和CEA的联合检测是筛检肺癌的优化组合,对肺癌的早期诊断有较高的临床应用价值。Objective To investigate the application of multi - tumor markers protein chip diagnose system in diagnosing lung cancer. Methods Using the multi-tumor markers protein chip diagnose system to determine and analyze the concentration values of 12 tumor markers in the sera of 30 lung cancer and 50 benign lesion patients, and 40 normal persons. Results The difference of CA125, CA153, CA242, CEA and FER was statistically significant between lung cancer groups and other two groups（P 〈0.01 ） , The positive rate of the allied detection was 80% , about 30% higher than the independent items. Conclusion The allied detection of CA125 ,CA153,CA242 and CEA was the best combination for the diagnosis of lung cancer.

关 键 词：肺癌 肿瘤标志物 生物芯片诊断 

分 类 号：R734.2[医药卫生—肿瘤]