层黏连蛋白受体与胃癌侵袭转移的关系及定量研究  

Correlation Between Laminin Receptors and Invasion and Metastasis of Gastric Cancer

作　　者：徐晓艳[1] 夏养志[1] 马秀梅[1] 

机构地区：[1]内蒙古医学院基础医学院病理教研室,内蒙古呼和浩特010059

出　　处：《内蒙古医学杂志》2007年第12期1422-1424,F0004,共4页Inner Mongolia Medical Journal

摘　　要：目的：研究层黏连蛋白受体在胃癌中的表达，探讨其与胃癌侵袭及淋巴结转移的关系。方法：采用免疫组化S—P法，检测96例胃腺癌组织中层黏连蛋白受体的表达情况；应用图像分析技术来分析这个指标在胃癌中的阳性表达率。结果：经四格表工0检验层黏连蛋白受体在胃癌组织中的高表达与浸润深度、分化程度密切相关（P〈0．05～0．01），与淋巴结转移无关（P〉0．05）；而层黏连蛋白受体的IRS经t检验与浸润深度、分化程度、淋巴结转移密切相关（P〈0．05～0．01）。结论：胃癌组织中层黏连蛋白受体高表达参与并影响了胃癌的侵袭和转移。Objective：To investigate the expression of laminin receptors in gastric cancer, for exploring the correlation between laminin receptors and invasion of gastric cancer and matastasis of lymphones. Methods： The expression of laminin receptors in 96 cases of gastic cancer were detected by S-P methods. The positive rate of expression of the laminin receptors was analyzed with image analysis technique. Results： The results in X2 test in fourfold table showed the high expression of laminin receptor in gastric cancer tissues was closely related to the invasion and differentiation （P〈0.05）, but no related to metastasis of lymphones （p〈0.05）. The IRS of laminin receptor was correlated with invasion, differentiation and matastasis of lymphones by t test（P 〈 0.05）. Conclusion： The high expression of liminin receptors in gastric tissues involves in invasion and metastasis of gastric cancer.

关 键 词：层黏连蛋白受体 胃癌 免疫组化 图像分析技术 

分 类 号：R735.2[医药卫生—肿瘤]